Opioid Equianalgesic Doses
| OPIOID EQUIANALGESIC DOSES | ||
|---|---|---|
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All equivalencies should be considered approximations only and can be affected by interpatient variability, type of pain (ie, acute vs. chronic), chronic administration, tolerance, etc. Patients should be monitored for efficacy and adverse reactions and the dose adjusted accordingly. |
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| GENERIC NAME | DOSE EQUAL TO 10mg IM OF MORPHINE SULFATE | |
| ORAL | INJECTION (IM/IV/SC)1 | |
| MORPHINE2 | 60mg (30mg) | 10mg |
| CODEINE | 200mg | 130mg |
| FENTANYL3 | N/A | 0.1mg (100micrograms) |
| HYDROCODONE4 | 30mg | N/A |
| HYDROMORPHONE | 7.5mg | 1.5mg |
| LEVORPHANOL | 4mg | 2mg |
| MEPERIDINE | 300mg | 75mg |
| METHADONE | 20mg | 10mg |
| OXYCODONE | 30mg | N/A |
| OXYMORPHONE5 | 10mg | 1mg |
| NOTES | ||
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1Although controlled studies are not available, in clinical practice it is customary to consider the doses of opioids given IM, IV, or SC to be equivalent. There may be some differences in pharmacokinetic parameters such as Cmax and Tmax.
2The conversion ratio of 10mg parenteral morphine = 30mg oral morphine is based on clinical experience in patients with chronic pain. The conversion ratio of 10mg parenteral morphine = 60mg oral morphine is based on a potency study in acute pain. 3See literature for conversion of fentanyl transdermal patch, buccal tablets, buccal soluble film, sublingual tablets, units for transmucosal administration, and nasal spray. 4Hydrocodone not available as a single entity product. 5The 10mg conversion value of oxymorphone applies to oral and rectal dosing. (Rev. 5/2012) |
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