Ophthalmic Disorders

Humira Approved for the Treatment of Pediatric Uveitis

By October 17, 2018

The approval was based on data from a randomized, double-masked, placebo-controlled study of 90 pediatric patients aged 2 to < 18 years with active JIA-associated non-infectious uveitis.

NDA Submitted for Dry Eye Disease Treatment KPI-121 0.25%

By October 16, 2018

The NDA includes data from one Phase 2 and two Phase 3 clinical trials (STRIDE 1 and STRIDE 2) involving ~2000 individuals with dry eye disease.

Yutiq Approved for Chronic, Non-Infectious Posterior Segment Uveitis

By October 15, 2018

The approval was based on data from 2 sham injection-controlled, double-masked Phase 3 trials.

Adherence to Mediterranean Diet May Lower AMD Risk

October 04, 2018

Participants with a high MeDi score showed a significantly reduced risk for incident advanced AMD versus participants with a low score (range, 6 to 9 vs 0 to 3) in the fully adjusted model using data for both the RS-I and Alienor Study (hazard ratio, 0.59).

Glaucoma Treatments

September 27, 2018

Glaucoma treatment chart (alpha2-agonists, beta blockers, carbonic anhydrase inhibitors, cholinergic agonists, prostaglandin analogs).

Xelpros Approved for Open-Angle Glaucoma, Ocular Hypertension

By September 14, 2018

Xelpros contains latanoprost, a prostaglandin F2α analogue that is believed to reduce IOP by increasing the outflow of aqueous humor.

FDA to Review Eylea for the Treatment of Non-Proliferative Diabetic Retinopathy

By September 14, 2018

The sBLA includes results from the Phase 3 PANORAMA trial, which enrolled 402 patients with NPDR.

Bacterial Conjunctivitis Treatments

August 30, 2018

Bacterial conjunctivitis treatment chart for topical medications.

Inveltys Approved for Post-Op Pain, Inflammation After Ocular Surgery

By August 24, 2018

Data from two Phase 3, multicenter, randomized, double-masked, placebo-controlled trials showed a greater proportion of patients treated with Inveltys having complete resolution of ocular inflammation.

Oxervate Approved for the Treatment of Neurotrophic Keratitis

By August 23, 2018

The safety and efficacy of Oxervate was evaluated in 2 independent, double-masked, randomized, multicenter, controlled clinical trials involving patients with moderate to severe neurotrophic keratitis.

FDA Approves Additional Dosing Schedule for Eylea in Wet AMD

By August 17, 2018

The approval was supported by year 2 data from the Phase 3 VIEW 1 and VIEW 2 trials that evaluated 2412 patients with wet AMD who followed a modified 12-week dosing schedule (doses at least every 12 weeks and additional doses as needed).

Doctors Remove Contact Lens Embedded in Eyelid for Years

August 17, 2018

The woman couldn't recall how the contact lens got there or how long it was there, but her mother remembered that she had been hit in the eye with a shuttlecock during a game of badminton 28 years ago.

FDA Approves Cequa for the Treatment of Dry Eye Disease

By August 16, 2018

Cequa was evaluated in 2 multicenter, randomized studies involving 1,048 patients with dry eye disease.

Refresh Repair Lubricant Eye Drops Now Available for Dry Eye

By July 10, 2018

The new ocular drops contain carboxymethylcellulose (CMC) 0.5%, hyaluronic acid (HA), glycerin 0.9%, and other organic osmoprotectants.

Ophthalmologists Warn About Eye Injury Risk With Fireworks

July 03, 2018

American Academy of Ophthalmology recommends wearing protective eyewear, keeping safe distance

Allergic Conjunctivitis Treatments

June 26, 2018

A comparative dosing chart of prescription and over-the-counter (OTC) medications for allergic conjunctivitis treatment.

Corneal Abnormalities Seen With Down Syndrome

June 25, 2018

There were differences in steepest keratometry of 47.35 diopters in patients with DS vs 43.7 diopters in control subjects. There were also differences in corneal pachymetry of 503µm in patients with DS versus 545µm in controls.

Amblyopia, Strabismus May Slow Test Performance in Children

June 15, 2018

Compared with children in the control group, children with amblyopia had a slower mean time to completion (P=.001), as did children with non-amblyopic strabismus (P=.002).

Implant to Reduce Intraocular Pressure in Glaucoma Shows Promise

By June 13, 2018

The trial included 594 individuals with open-angle glaucoma or ocular hypertension. Participants were randomized to receive 3 administration cycles (Day 1, Week 16 and Week 32) of Bimatoprost SR or twice daily timolol eye drops.

Treatment for Limbal Stem Cell Deficiency Gets Orphan Drug Designation

By June 12, 2018

GPLSCD01 is an investigational treatment made up of ex vivo expanded autologous human corneal epithelial cells containing stem cells.

Time Spent in Education Is Causal Risk Factor for Myopia

June 07, 2018

A U.K. university graduate with 17 years of education would be at least −1 dioptre more myopic, on average, than someone who left school at age 16 with 12 years of education.

First Artificial Iris FDA-Approved for Aniridia, Other Iris Defects

By May 31, 2018

In a clinical trial of 389 individuals with iris defects, 70% of patients reported a significant decrease in light sensitivity and glare.

Uveal Effusion Reported After Initiation of Anti-PD-1, -PD-L1

May 11, 2018

The patients were 2 white men aged 52 and 85 years with metastatic cutaneous melanoma and a 68-year-old African-American man with metastatic adenocarcinoma of the lung. All 3 patients were receiving anti-PD-1 and anti-PD-L1 monoclonal antibody therapy.

Bacterial Conjunctivitis Treatment Currently in Shortage

By May 09, 2018

Azasite, supplied as a 2.5mL solution, contains benzalkonium chloride. It is indicated for use in susceptible bacterial conjunctivitis.

Unique Treatment for Ocular Redness Now Available Over-the-Counter

By May 07, 2018

Lumify is the first OTC eye drop to contain low-dose brimonidine, an alpha-2 adrenergic receptor agonist.

Eyes of Ebola Survivors Show Localized Pathological Changes

May 07, 2018

All lesions respected the horizontal raphe, and the fovea was spared. A V-shaped hyperreflectivity of the outer nuclear layer was seen with OCT imaging, overlying discontinuities of the ellipsoid zone and interdigitation zone in smaller lesions.

Rhopressa Now Available for Open-Angle Glaucoma, Ocular Hypertension

By April 30, 2018

The approval was based on results from 3 randomized trials which found that Rhopressa was associated with a reduction in intraocular pressure of up to 5mmHg.

FDA Fast Tracks Gene Therapy for X-Linked Retinitis Pigmentosa

By April 27, 2018

XLRP represents the most severe form of retinitis pigmentosa (RP), an inherited retinal disease characterized by progressive retinal degeneration and vision loss that ends in complete blindness.

Dark Chocolate Can Improve Contrast Sensitivity, Visual Acuity

April 27, 2018

Visual acuity improved slightly more after consumption of dark vs milk chocolate.

One-Hour Plasma Glucose Useful Predictor of Diabetic Retinopathy

April 16, 2018

The researchers found that the prevalence and incidence of DR changed in a similar manner across the distributions of 1h-PG and 2h-PG concentrations.