Generic Name and Formulations:
Pegaspargase 750 IU/mL; soln for IV or IM inj; preservative-free.
Company:
Enzon Pharmaceuticals
First-line acute lymphoblastic leukemia (including patients with asparaginase hypersensitivity).
Give by IV inj over 1–2 hours or by IM inj (max 2mL/inj site). 2500 IU/m2 no more frequently than every 14 days.
Enzyme.
History of pancreatitis, serious hemorrhage, or thrombosis with prior L-asparaginase therapy.
Have resuscitation equipment available and observe patient for 1 hour post-dose. Monitor coagulation parameters. Discontinue if serious allergic reactions, thrombotic events, or pancreatitis occurs. Pregnancy (Cat.C). Nursing mothers: not recommended.
Allergic reactions (including anaphylaxis), hyperglycemia, pancreatitis, CNS thrombosis, coagulopathy, hyperbilirubinemia, elevated transaminases.
Single-use vial (5mL)—1