OFIRMEV Rx

Indications for OFIRMEV:

Management of mild to moderate pain or moderate to severe pain with adjunctive opioid analgesics. Fever.

Adult Dose for OFIRMEV:

Give by IV infusion over 15 minutes. <50kg: 15mg/kg every 6 hours (or 12.5mg/kg every 4 hours); max single dose: 15mg/kg (up to 750mg), max daily dose: 75mg/kg/24 hours (up to 3750mg). ≥50kg: 15mg/kg every 6 hours (or 650mg every 4 hours); max single dose:1000mg, max daily dose: 4000mg/24 hours. Minimum dosing interval: 4 hours.

Children's Dose for OFIRMEV:

Give by IV infusion over 15 minutes; small volume doses (up to 60mL), place in syringe and administer using syringe pump. <2yrs: not studied. ≥2yrs: 15mg/kg every 6 hours (or 12.5mg/kg every 4 hours); max single dose: 15mg/kg, max daily dose: 75mg/kg/24 hours. Minimum dosing interval: 4 hours.

Pharmacological Class:

Analgesic/antipyretic.

Contraindications:

Severe hepatic impairment. Severe active liver disease.

Warnings/Precautions:

Hepatic impairment. Active hepatic disease. Alcoholism. Chronic malnutrition. Severe hypovolemia. Severe renal impairment (CrCl≤30mL/min). Labor & delivery. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Caution with CYP2E1 inhibitors or inducers. Doses of 4000mg/day may increase INR, monitor warfarin.

Adverse Reactions:

GI upset, headache, insomnia; also children: constipation, pruritus, agitation, atelectasis; hepatotoxicity (with high doses), anaphylaxis.

How Supplied:

Single-use vials (1000mg/vial)—24