Positive Results for Potential Bacterial Vaginosis Treatment Announced

Symbiomix announced positive results from the second pivotal Phase 3 trial of SYM-1219 (secnidazole) for the treatment of bacterial vaginosis (BV).

Maternal β-Cells Expansion Tied to Prolactin Receptor Signaling

Prolactin receptor (PRLR) signaling plays a role in expansion of maternal β-cells during pregnancy, according to a study published online in Diabetes.

Prenatal Smoking May Up Schizophrenia Risk in Offspring

In the most definitive study to date, cigarette smoking during pregnancy was linked to a greater likelihood of schizophrenia in offspring. Those are the findings of a new long-term study which assessed maternal nicotine exposure (via cotinine levels) during pregnancy.

Does Too Much Folate During Pregnancy Up Autism Risk?

Researchers from Johns Hopkins Bloomberg School of Public Health reported that too much folate in a new mother's body may increase a child's risk of developing an autism spectrum disorder. Findings from the study will be presented at the 2016 International Meeting for Autism Research.

Are Prophylactic Barbiturates Effective After Perinatal Asphyxia?

An updated Cochrane review found low or very low quality evidence.

Oral Postpartum Hemorrhage Treatment Now Available

Lupin Pharmaceuticals has announced the re-introduction of Methergine (methylergonovine maleate) Oral Tablets 0.2mg for the prevention and management of postpartum hemorrhage (PPH).

FDA Issues Advisory for Antifungal After Reports of Miscarriage Risk

The Food and Drug Administration (FDA) is advising caution when prescribing oral fluconazole (Diflucan) in pregnancy after evaluating data from a Danish study that indicated a possible increased risk of miscarriage when used to treat yeast infections.

Hospira Recalls Magnesium Sulfate Injection

Hospira announced a voluntary recall of one lot of 50% Magnesium Sulfate Injection, 10g/20mL (0.5/gmL), 20mL single-dose vials.

Dietary Supplements for Dysmenorrhea: Are Any Effective?

A Cochrane review found no high quality evidence to support the efficacy of any dietary supplement for dysmenorrhea.

Does Lamotrigine Use in Pregnancy Up Birth Defect Risk?

According to a study published in Neurology, babies born to pregnant women taking lamotrigine may not be at an increased risk of birth defects, such as a cleft lip, cleft palate or clubfoot.

SMFM Statement on Antenatal Corticosteroid Use During Late Preterm Period

The Society for Maternal-Fetal Medicine (SMFM) issued a statement on the use of antenatal corticosteroids during the late preterm birth period for women at risk of preterm birth.

Certain Antidepressants May Up Bone Loss During Lactation

Selective serotonin reuptake inhibitors (SSRIs) use during pregnancy and lactation can result in decreased bone density in mothers, increasing their risk of fractures later in life, a study presented at ENDO 2016 has found.

Risk of Asthma Associated With PCOS, Excess Weight

Polycystic ovary syndrome (PCOS) and excess weight have been independently linked with the onset of asthma, according to findings in a new study to be presented at the annual Endocrine Society meeting.

Radius Submits NDA for New Osteoporosis Tx in Postmenopausal Women

Radius Health announced the submission of a New Drug Application (NDA) to the Food and Drug Administration (FDA) for abaloparatide-subcutaneous (SC) 80mg, a once daily treatment for postmenopausal women with osteoporosis.

Avoid Compounded Hormone Meds for Menopausal Sx - Endocrine Society

The Endocrine Society has issued a statement advising clinicians to avoid administering compounded hormone medications to treat menopausal symptoms, female sexual dysfunction, and other hormone conditions.

More Exposure to "Sunshine Vitamin" for Mom May Lower Asthma Risk in Kids

Expecting mothers should make sure they get enough vitamin D exposure during the second trimester to reduce the child's likelihood of developing asthma, according to new research by the University of Kansas published in the American Journal of Health Economics.

Flu Vaccinations in Pregnant Women May Protect Against Stillbirths

Researchers from Western Australia reported that seasonal influenza vaccinations may protect against stillbirth.

Not All Migraine Meds Safe for Pregnant Women, Review Finds

Drugs that were once considered safe for pregnant women with migraines may not be, according to researcher at Wake Forest Baptist Medical Center.

Mifeprex Approved for Use Through 70 Days Gestation

The Food and Drug Administration (FDA) has approved the supplemental New Drug Application (sNDA) for Mifeprex (mifepristone; Danco Laboratories) including modifications to the risk evaluation and mitigation strategy (REMS) assessment.

Caffeine Consumption May Affect Miscarriage Risk

Researchers from the National Institutes of Health and Ohio State University report that the risk of miscarriage increases if couples consume over two caffeinated beverages a day in the weeks leading up to conception.

Obesity, Oral Contraceptives, and the Risk of Cerebral Venous Thrombosis

In women who use oral contraceptives, obesity is a strong risk factor for cerebral venous thrombosis.

Could a Male Birth Control Pill Soon Be Reality?

Strides are being made toward the development of a male oral contraceptive. Researchers at the University of Minnesota are making tweaks to experimental compounds already developed by the drug company Bristol-Myers Squibb (BMS), to produce a safe, soluble and fast-acting male contraceptive.

Mteryti Prenatal Vitamins Now Available

Duchesnay announced the launch of Mteryti and Mteryti folic 5 products to help optimize iron, calcium, and folic acid absorption for prenatal use.

FDA Orders Follow-Up Studies, Boxed Warning for Essure

In a new draft guidance, the Food and Drug Administration (FDA) announced that they have ordered Bayer to conduct follow-up studies for their permanent form of birth control, Essure.

Study Reveals Surprising Results for Female Libido Pill

How safe and effective is flibanserin (Addyi; Valeant) for the treatment of hypoactive sexual desire disorder (HSDD) in women?

Perimenopausal Symptoms and Treatments: A Review

A new review article explores the current research findings of perimenopausal women's symptoms and the treatment options available to reduce the impact they may have on quality of life.

First Egg-Based DHA Prenatal Vitamins Launched

Vertical Pharmaceuticals announced the launch of OB Complete Gold, prenatal vitamins providing the first egg-based docosahexaenoic acid (DHA).

Atazanavir Exposure in Utero May Have an Effect on Infant Development

Infants whose mothers took atazanavir had small but significant effects on language and social-emotional development, compared to other non-atazanavir-containing antiretroviral regimens, a study published in AIDS has shown.

Study Calls for Evidence-Based Contraception Guidelines for Epileptic Women

A study found that 30% of women with epilepsy did not use highly effective contraception though they are at an increased risk of having babies with fetal malformations due to their antiepileptic medications.

Elagolix Demonstrates Efficacy in 2nd Phase 3 Endometriosis Study

AbbVie and Neurocrine Biosciences announced positive top-line results from the second of two replicate Phase 3 clinical trials of Elagolix in premenopausal women with endometriosis-associated pain.

CDC Updates Interim Zika Virus Guidelines for Pregnant Women and Women of Reproductive Age

Serologic testing for Zika virus has been recommended in asymptomatic pregnant women, who have traveled to, or reside in, areas of ongoing transmission.

Study Finds Compelling Evidence to Change Skin-Prep Practices for C-Section

Authors of a new study argue their findings provide sufficient evidence to change standard skin-prep practices for C-sections, in order to avoid the ongoing risk of infection.

Early Flu Treatment May Reduce Hospital Stay for Pregnant Women

Early treatment with oseltamivir may reduce length of hospital stay for pregnant women with the flu, especially for severe cases, a new study reported.

More 'Evidence-Based' Guidelines Needed for Antidepressant Use During Pregnancy, Say CDC

The U.S. Centers for Disease Control and Prevention (CDC) has called for an increase in research on the potential risks of taking antidepressants during pregnancy.

Prenatal Vitamin D: Can It Reduce Child's Asthma Risk?

Two new trials have found no significant statistical reduction in cases of persistent wheezing and asthma where the mother had taken additional vitamin D supplements.

Asthma Med Use During Pregnancy Linked to Increased Autism Risk

Taking certain asthma medication during pregnancy could increase the risk of the child being diagnosed with autism spectrum disorder.

The Pill Does Not Up Birth Defects Risk, Study Finds

A new study has found that women who take oral contraceptives just before or during pregnancy do not have an increased risk of birth defects.

Increased Risk of Spontaneous Abortion Linked to Oral Antifungal, Study Finds

Using the oral antifungal medication fluconazole during pregnancy has been associated with an increased risk of spontaneous abortion.

Seizure Drug Recalled Due To Potentially Incorrect Barcode

Hospira announced a voluntary recall of one lot of Magnesium Sulfate in Water for Injection (0.235mEq Mg/mL) 40mg/mL 2g total, 50mL due to a potentially incorrect barcode.

Antidepressant May Up Birth Defect Risk if Taken in Early Pregnancy

Using the antidepressant paroxetine during the first trimester of pregnancy may increase the risk of major congenital and cardiac malformations in newborns.

Does Conception via Infertility Txs Increase Likelihood of Developmental Delays?

Children conceived via infertility treatments are no more likely to have a developmental delay than children conceived without such treatments.

Diabetes Drug May Help Prevent, Treat Preeclampsia

Metformin may potentially help prevent and treat preeclampsia, according to a study published in the American Journal of Obstetrics and Gynecology.

Autism Risk Increases With Antidepressant Use During Pregnancy

A large-scale study has found a link between antidepressant (AD) use during the second and/or third trimester of pregnancy and an increased risk of autism spectrum disorder (ASD) in children by 87%.

Smoking During Pregnancy Linked to Lower Fitness Levels in Sons

Young males whose mothers smoked during pregnancy had lower aerobic fitness compared to males whose mothers did not smoke, according to a study published in BJOG: an International Journal of Obstetrics and Gynaecology.

Promising Results in Phase 3 Trial for Novel Estradiol Softgel

A Phase 3 Rejoice Trial of TX-004HR (estradiol) to treat moderate to severe dyspareunia (vaginal pain during sexual intercourse), has had positive top-line results.

Can Estrogen Help Cut Relapses in Multiple Sclerosis?

A Phase 2 clinical trial has shown how the pregnancy hormone estriol can help patients with relapsing-remitting multiple sclerosis (RRMS) avoid relapses.

USPSTF Calls for More Research in These 5 Women's Health Issues

The United States Preventive Services Task Force (USPSTF) released its annual Report to Congress reporting on 5 high-priority evidence gaps regarding women's health.

Healthy Weight Before, During Pregnancy Reduces Infant Death Risk

Healthy weight management before getting pregnant and appropriate weight gain during pregnancy significantly reduce the risk of infant death.

How Previous Pill Use Affects Ovarian Cancer Outcomes

Compared to those who had not been on oral contraceptives, patients who had taken the pill had improved progression-free survival as well as overall survival.

Antibiotic Class Not Linked to Increased Risk of Birth Defects

A new study has found that the two most commonly prescribed antibiotics are not associated with an increased risk of adverse outcomes in pregnant women.

ACOG: Committee Opinion Highlights Importance of Contraceptive Implants, IUDs

Ob-Gyns may help lower unintended pregnancy rates by increasing access to contraceptive implants and intrauterine devices (IUDs) for patients, according to a Committee Opinion paper released by ACOG.

AAP Advises No Alcohol at All During Pregnancy

The American Academy of Pediatrics (AAP) has issued a new clinical report in the November issue of Pediatrics emphasizing that no amount of alcohol should be considered safe to drink during any trimester of pregnancy due to the risk of fetal alcohol spectrum disorders (FASDs).

Addyi Tablets Now Available for Female HSDD

Sprout announced that that Addyi (flibanserin) tablets are now available for the treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women.

Drug Interactions in Placenta Could Pose Risk for Fetus

Research in the American Society for Microbiology's journal Antimicrobial Agents and Chemotherapy found that pregnant women taking antiviral medications to treat hepatitis C (HCV) and/or HIV with non-steroidal anti-inflammatories (NSAIDs) or antihypertensives may have an increased risk of birth defects or stunted fetal growth, although these antiviral drugs have not been shown to directly cause harm to a fetus.

New Clinical Practice Guideline Details Menopausal Therapy Options

A new clinical practice guideline has been issued by the Endocrine Society on the treatment of menopausal symptoms.

As More States Cover Immediate Postpartum Contraception, Challenges Arise

As more states implement specific Medicaid reimbursement practices for immediate postpartum long-acting reversible contraception (LARC) such as intrauterine devices (IUDs) and implants, researchers from the University of Michigan Health System have identified challenges for agencies and providers alike in a study published in Contraception.

Infants Born to Mothers Exposed to This HIV Drug May Have Lower Bone Mass

According to a National Institutes of Health (NIH) Study, infants exposed in the womb to the HIV drug tenofovir disoproxil fumarate, may have lower bone mineral content than those exposed to other anti-HIV drugs.

For Genitourinary Menopausal Symptoms, Method of Tx Matters for Adherence

Research presented at the 2015 Annual Meeting of The North American Menopause Society (NAMS) supports previous findings that use of local estrogens for genitourinary symptoms of menopause (vaginal dryness, painful intercourse, and urinary tract infections) are underutilized, but the study also reports that method of local treatment can impact treatment duration and adherence to therapeutic guidelines.

New Procedure for Preeclampsia Promising in Pilot Study

A pilot study in the Journal of the American Society of Nephrology outlines one of the first therapeutic interventions for preeclampsia that could allow women to safely prolong their pregnancy via removal of soluble Fms-like tyrosine kinase-1 (sFlt-1) from the blood via apheresis.

FDA Committee Meets to Discuss Essure Safety, Efficacy

Bayer HealthCare announced that a recent Food and Drug Administration (FDA) Advisory Committee met to review and discuss data regarding the benefits and risks associated with use of the Essure medical device for hysteroscopic sterilization.

Small But Significant Stroke Risk Seen With Oral Contraceptives

An updated report in MedLink Neurology stated that oral contraceptives are associated with a small but significant increase in ischemic stroke risk, particularly for women who smoke, have hypertension, or a history of migraine headaches.

First Trimester Screening May Prevent Pregnancy Complications

Placental vascular disorders during early pregnancy is associated with increased risk of developing serious obstetric complications, a study from The American Journal of Pathology reported.

Flavonoid Could Lower Cancer Risk in Postmenopausal Women

A flavonoid commonly found in fruits and vegetables shows promise in reducing the risk of breast cancer in postmenopausal women, according to new research published in Springer Plus.

Safe and Effective Treatments for PMDD: A Review

An in-depth review of the safety and efficacy of treatments for premenstrual dysphoric disorder (PMDD) has been published in the Journal of Psychiatric Practice.

Novel Antibiotic Fast Tracked for Bacterial Vaginosis

The Food and Drug Administration (FDA) has granted SYM-1219 (secnidazole, Symbiomix) Fast Track designation for the treatment of bacterial vaginosis (BV).

When Should Pregnant Patients Worry About Headaches?

Based on a new study published in Neurology, researchers have developed the first clinical recommendations for making diagnostic decisions regarding headaches in pregnant women.

FDA Approves Addyi for Women with Hypoactive Sexual Desire Disorder

The Food and Drug Administration (FDA) has approved Addyi (flibanserin) for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty and is not due to a co-existing medical or psychiatric condition, problems within the relationship, or the effects of a medication or other drug substance.

Microbiome May Help ID Women At Risk for Preterm Delivery

Significantly different microbiomes were seen in the reproductive tracts of pregnant women who had a baby born prematurely vs. women who delivered full term.

New App Predicts Woman's Risk of Pregnancy Each Day

Cycle Technologies announced the launch of Dot, a period-tracking and fertility app to evaluate a woman's risk of pregnancy for each day of her cycle.

GERD Risk Jumps in Women After IVF - But Why?

Women who conceive following in vitro fertilization (IVF) are significantly more likely to develop gastroesophageal reflux disease (GERD) at least one year after delivery, although the risk does not vary with singleton and twin births, according to a study in the United European Gastroenterology Journal.

X-Ray Exposure to Fetus Not Linked to Harmful Effects, Study Finds

A new study in the Journal of the American Academy of Orthopaedic Surgeons (JAAOS) suggests that imaging studies used to diagnose traumatic injuries sustained by pregnant women are safe when used properly.

Which Drugs Are Most Commonly Prescribed to Pregnant Women?

Results from a cohort study evaluating over one million pregnant women enrolled in Medicaid revealed that nitrofurantoin was the most commonly dispensed medication during pregnancy.

New Findings on CCB Use in Late Pregnancy, Neonatal Seizure Risk

Contrary to prior research, a study appearing in Obstetrics & Gynecology reports no increased risk of seizures in neonates born to mothers exposed to calcium channel blockers (CCBs) in late pregnancy.

Oral Contraceptives Could Protect Against Endometrial Cx for Decades

An analysis has found that using oral contraceptives for even a few years can give long-term protection against endometrial cancer, showing greater risk reduction with longer use.

SSRI in Pregnancy Linked to Fewer Preterm Births, But Increase in Other Risks

The use of selective serotonin reuptake inhibitors (SSRIs) to treat maternal psychiatric disorders was linked to a lower risk of preterm birth and a delivery but a higher risk of neonatal problems.

Vitamin D May Not Benefit Postmenopausal Women

Postmenopausal women did not experience beneficial effects on bone mineral density, muscle function, muscle mass or falls with high-dose vitamin D, according to a study published in JAMA Internal Medicine.

Many New Mothers Not Receiving Advice From Clinicians

Many new mothers do not receive advice from clinicians on infant care or receive advice from healthcare professionals or family members that is not consistent with recommendations and guidelines, reports a new study in Pediatrics.

Fewer Teens Having Sex, But More Using Emergency Contraception

Use of emergency contraception by female teenagers has increased over the past decade while the percentage of both male and female teenagers who have had sexual intercourse has decline since 1988, according to new data from the Centers for Disease Control and Prevention's (CDC) National Center for Health Statistics (NCHS).

Investigational Menopause Drug Targets Brain Only

An investigational drug to treat hot flashes and other menopausal symptoms selectively delivers estrogen only to the brain, sparing other organs from hormone exposure and potential side effects.

Newborn's First Stool Could Signal Future Cognitive Problems

A baby's first stool may indicate that the child could have difficulty in cognitive development, new research from the Case Western Reserve University Project Newborn has shown.

Diabetes Drug May Not Prevent Birth of Overweight Babies

Giving antidiabetic drugs to obese pregnant women may not prevent their babies from being born overweight, according to a study published in The Lancet Diabetes and Endocrinology.

Small Risk of Birth Defects Seen With Some Antidepressants in Early Pregnancy

A study in BMJ reports that an increased risk of birth defects was seen with use of some selective serotonin reuptake inhibitors (SSRIs) during early pregnancy, but that the absolute risk is still low if the association is indeed causal.

Caya Contoured Diaphragm Available for Contraception Up to 2 Years

HPSRx announced the launch of Caya, a non-hormonal contoured diaphragm for use as a female contraceptive barrier device for up to two years.

Out-of-Pocket Costs for Contraceptives Drop After ACA

A significant drop in out-of-pocket spending for oral contraceptives and intrauterine devices (IUDs) has been evident since the Affordable Care Act (ACA) went into effect, according to a study published in Health Affairs.

Alternate Confirmation Test for Essure Gets Nod from FDA

Bayer HealthCare announced that the Food and Drug Administration (FDA) has approved an alternate confirmation test for Essure inserts, administered three months following the procedure for hysteroscopic sterilization.

Obese Teens Less Likely to Use Contraception Than Peers

There appears to be a difference in contraception use among female adolescents based on weight, as new research appearing in the Journal of Pediatrics found that sexually active obese adolescents were significantly less likely to use contraception compared to their normal weight peers.

FDA Approves New Combination Oral Contraceptive

The Food and Drug Administration (FDA) has approved Tri-Lo-Estarylla (ethinyl estradiol, norgestimate; Sandoz) tablets for oral contraception.

C-Section and Autism Risk: Are They Related?

Children who were born via cesarean section delivery were 21 percent more likely to be diagnosed with autism spectrum disorder (ASD) but this link was not found to be causal upon further analysis of sibling pairs, new research has found.

New Pelvic Muscle Training Device Available for Urinary Incontinence

The PeriCoach System is now available to strength and tone pelvic muscles in women with urinary incontinence following its approval in March 2015.

Swift Birth Control Implantation Postpartum Could Have Big Financial Savings

A computer model predicts that offering women immediate postpartum etonogestrel implant insertion could be extremely cost-effective for both new mothers and medical insurance companies.

ADHD Drug Helps Women With Menopause-Related Cognitive Issues in Study

A drug indicated for the treatment of attention deficit hyperactivity disorder (ADHD) and binge eating disorder also helped women with executive functions related to menopause in research appearing in the journal Psychopharmacology.

Women Wishing to Conceive May Want to Avoid These Pain Meds, Study Suggests

A study presented at the European League Against Rheumatism Annual Congress (EULAR 2015) indicates that use of some non-steroidal anti-inflammatory drugs (NSAIDs) could have a negative impact on female fertility, even with short-term use.

Does Eating Placenta Really Help Moms Postpartum?

Interest in potential health benefits with consuming the placenta postpartum has increased in recent years, but a review in the Archives of Women's Mental Health found inconclusive data on the perceived health benefits with placentophagy.

Third Time's a Charm for Female Libido Drug Flibanserin

The Food and Drug Administration (FDA) Advisory Committee has voted 18-6 in favor of approving flibanserin, an investigational agent for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women if certain risk management options beyond labeling are implemented.

SSRI Use in Late Pregnancy Linked to PPHN, But Risk is Small

While a new study appearing in the Journal of the American Medical Association suggests that use of antidepressants in late pregnancy may be associated with an increased risk of persistent pulmonary hypertension of the newborn (PPHN), the absolute risk is small and the risk increase appears to be less than previous studies have suggested.

Antiviral Prevents Mother-to-Infant Transmission of HBV in Study

Research published in Clinical Gastroenterology and Hepatology showed that nearly all pregnant women with hepatitis B virus (HBV) taking telbivudine had undetectable levels of HBV DNA in cord blood, with no severe adverse events or complications observed in women or infants.

Do Vitamin D, Calcium Supplements Reduce Menopausal Symptoms?

Vitamin D and calcium supplements do not appear to reduce menopausal symptoms in older women, reports a new study published in Maturitas, the official journal of the European Menopause and Andropause Society.

APAP Use During Pregnancy May Have Adverse Effect on Male Babies

Prolonged acetaminophen use (1 week) by pregnant women may suppress fetal testosterone production, according to researchers from the University of Edinburgh.

Drop in Codeine Rx to Postpartum Women Seen After FDA Advisory

A new study in JAMA reports that a significant reduction in the rate of dispensing of codeine to postpartum women was observed following public health advisories from the U.S. Food and Drug Administration (FDA) and Health Canada on potentially life-threatening adverse effects in infants of breastfeeding mothers taking codeine.

Study: 9-Valent HPV Vaccine Could Prevent 80% of Cervical Cancers

A study by the Centers for Disease Control and Prevention (CDC) and Cedars-Sinai proposes that the 9-valent human papillomavirus (HPV) vaccine could prevent 80 percent of cervical cancers in the United States if administered to all 11- or 12-year-old children prior to exposure to the virus.