Bulletin Provides Guidelines for Second-Trimester Abortion

New evidence-based guidelines provide guidance on medical and surgical methods for second-trimester abortion and management of associated complications.

In Utero Smoke Exposure Ups Subsequent Health Risks

In utero exposure to cigarette smoking puts women at higher risk of subsequently developing gestational diabetes or obesity in adulthood.

ACOG: Hormone Therapy Not Recommended to Prevent CHD

Menopausal hormone therapy should not be used for prevention of coronary heart disease.

Midlife Hysterectomy Doesn't Increase Cardiovascular Risk

A hysterectomy in midlife with or without ovarian conservation is unlikely to accelerate women's cardiovascular disease risk.

Iodine Deficiency Has Negative Impact on Child Cognition

Even mild iodine deficiency during pregnancy is associated with adverse child cognitive development.

CDC Report Reveals Smoking, Obesity Trends in U.S. Adults

In 2008-2010, the prevalence of key health behaviors among U.S. adults varied, with about one in five adults current smokers and 62.1% overweight or obese.

FDA-Approved Morning Sickness Drug Now Available

Diclegis (doxylamine succinate and pyridoxine HCl; Duchesnay USA) delayed-release tablets are now available across the country.

In Obese, Weight Loss Improves Reflux Symptoms

Obese and overweight adults can improve symptoms of gastroesophageal reflux disease by losing weight, while regaining even small amounts of weight can worsen symptoms.

Vitamin D May Be Beneficial in Crohn's Disease

For patients with stable Crohn's disease, vitamin D supplementation is associated with improvements in hand-grip strength, fatigue, and quality of life.

Combination Therapy Improves Bone Density with Osteoporosis

Combination therapy with teriparatide and denosumab may be most effective in treating postmenopausal women with osteoporosis at risk for fracture.

Pelvic Organ Prolapse Surgery Loses Effectiveness

In women with pelvic organ prolapse who undergo abdominal sacrocolpopexy, the failure rates increase with longer follow-up.

Mild Iodine Deficiency Can Affect Child's Cognition

Even mild iodine deficiency during pregnancy can have long-term adverse effects on a child's cognition.

NDA for Progestin-Only Patch Accepted for Filing by FDA

The FDA has accepted for filing Actavis' NDA for a once-weekly progestin-only transdermal contraceptive patch to prevent pregnancy in women.

Better In Vitro Outcomes by Single-Embryo Transfer

Women who undergo in vitro fertilization by transfer of a single embryo that has undergone screening for genetic abnormalities have significantly better obstetric and neonatal outcomes than women who receive two embryos.

How Much Nutrition in Diet Impacts Fertility

Fecundity seems to be related to the nutritional components of diet, with high protein intake linked to improved blastocyst development and pregnancy rates.

Study Explores Target Oxygen Saturation Levels for Preemies

For extremely preterm infants, the optimal target oxygen saturation levels are unclear.

New Pregnancy Test Can Tell When Fertilization Occurred

Clearblue Advanced Pregnancy Test with Weeks Estimator not only tells a woman if she is pregnant but also estimates the number of weeks since ovulation.

Low-Dose Birth Control Pills Could Increase Pelvic Pain Risk

Taking low-dose oral contraceptives may increase the risk of pelvic pain symptoms and pain during sexual climax.

Gene Variants Linked to Reduced Male Fertility

Particular gene variants of follicle stimulating hormone and its receptor are associated with significantly reduced fertility in men.

Low Birth Weight Accounts for Part of Intellectual Disability

Low birth weight is associated with about 10-15% of the total prevalence of intellectual disability among children who received a life-saving intervention in their first five years of life.

Plan B One-Step Now Available OTC for Women Age 15 and Older

The FDA approved an amended application to market Teva's Plan B One-Step for use without a prescription by women 15 years or older.

Outcomes Often Good for Extremely Premature Infants

About three-quarters of infants born extremely prematurely who receive active care have mild or no neurodevelopmental disability at 2.5 years of age.

AAP Issues Guidelines for Care of Infants Born at Home

Every newborn infant, including those born at home, is entitled to appropriate care.

Teen Moms More Likely to Be Subsequently Overweight

Teen mothers are more likely to be overweight or obese later in life compared to women who do not give birth as a teen.

Sonogram Best Modality for Diagnosing Ectopic Pregnancy

For pregnant women with abdominal pain or vaginal bleeding, transvaginal sonography is the best modality for diagnosing ectopic pregnancy.

Maternal Use of Valproate Ups Risk of Autism in Offspring

Prenatal exposure to valproate correlates with an increased risk of autism spectrum disorder and childhood autism in offspring.

Since HPV Vaccination, Drop Seen in Genital Warts in Young Women

For Australian women aged ≤30 years there has been a decrease in the proportion found to have genital warts following the introduction of the human papillomavirus (HPV) vaccine program.

One-Year Survival Up for Critical Congenital Heart Defects

For infants with critical congenital heart defects (CCHDs), one-year survival has improved over time, with an increased risk of mortality associated with earlier diagnosis, low birth weight, and maternal age.

Low-Carb Diet Doesn't Improve Gestational Diabetes Outcomes

A low carbohydrate diet does not alter insulin needs or pregnancy outcomes in women with gestational diabetes mellitus.

Phase 3 Data Released for In Vitro Fertilization Drug Milprosa

Teva released data from a sub-analysis of a Phase 3 clinical trial of Milprosa vaginal ring, an investigational, once-weekly therapy for luteal phase support in women undergoing in vitro fertilization.

Fewer Induced Abortions in RA Patients Exposed to Methotrexate

For women with rheumatoid arthritis, exposure to methotrexate is associated with a reduced risk of induced abortions.

Longer Breastfeeding Duration Boosts Risk of Iron Deficiency

Longer breastfeeding duration is associated with increased odds of iron deficiency in healthy children.

Music Aids Preemie Physiological, Developmental Function

For premature infants, exposure to live music and parent-preferred lullabies can influence physiological and developmental function.

Full-Term Gestational Age Tied to Development at 12 Months

For healthy full-term infants, development at age 12 months is associated with gestational age, with scores increasing for each additional week of gestation.

Laparoscopic Hysterectomy Rates on Rise Over Past Decade

The rate of laparoscopic hysterectomy has greatly increased over the past decade and is now higher than that of abdominal hysterectomy.

4.4 mmol/L Is Optimal Fasting Glucose Cutoff for GDM Screening

A fasting plasma glucose value of 4.4mmol/L is the optimal cut point for determining which pregnant Chinese women need a 75-g 2-h oral glucose tolerance test offered at 24-28 weeks' gestation.

Ectopic Pregnancy Rates Higher in Medicaid Population

The ectopic pregnancy rate is higher among Medicaid beneficiaries than the privately insured.

Blood Clot Risk During Pregnancy Is Highest Following Stillbirth

The risk of venous thromboembolism among pregnant women is highest if they have had a stillbirth. Risks also increase if the women are obese or have conditions such as varicose veins, inflammatory bowel disease, obstetric hemorrhage, preterm delivery, or cesarean section.

Polymorphism in Estrogen Receptor α Linked to Back Pain

For women with degenerative spondylolisthesis, polymorphisms in the estrogen receptor α (ERα) are associated with back pain intensity.

Collaborative Program Can Cut Early-Term Deliveries

A multistate collaborative process improvement program can reduce the rate of elective scheduled singleton early-term deliveries.

LQTS Susceptibility Mutations ID'd in Intrauterine Death

Missense mutations associated with long QT syndrome (LQTS) susceptibility may explain some cases of intrauterine fetal death.

Exercise Tied to Reduced Estrogens Post-Menopause

For post-menopausal women, increased physical activity is associated with lower levels of estradiol and estrone and with lower levels of specific estrogen metabolites.

Leukemia, Other Pediatric Cancers Linked to Air Pollution

Increased exposure to air pollution during pregnancy and the first year of life is associated with an increased risk of pediatric acute lymphoblastic leukemia, germ cell tumors, and retinoblastoma.

FDA Approves Diclegis for Morning Sickness; First Treatment OK'd in 30 Years

Diclegis, a tablet for women for the treatment of nausea and vomiting during pregnancy, has been approved by the FDA. Manufactured by Duchesnay USA, it is the only FDA-approved treatment for "morning sickness" in over 30 years.

Judge's Ruling to Remove Age Restriction on Morning-After Pill

A U.S. District Court judge has reversed a decision that restricted over-the-counter access to Teva's Plan B and Plan B One-Step tablets. Judge Edward Korman ordered the FDA to make levonorgestrel-based emergency contraceptives available without a prescription and without point-of-sale or age restrictions within the next 30 days.

Integrated Model Can Predict Preeclampsia in First Trimester

An integrated model for first-trimester screening of preeclampsia (PE) seems effective in a routine care setting.

Study: One in Five Teen Births Is Now a Repeat

Despite a decline in the prevalence of repeat teen births in recent years, nearly 20% of all teen births are a repeat birth with significant racial/ethnical and geographical variations.

Most Older U.S. Teens Are Now Sexually Active

Among those under 12 years old, sexual activity was rare, and most was nonconsensual. Most teens aged 17-19 years were found to be sexually active, while about 30% of 15- to 16-year-olds reported having had sex.

Physical Activity Improves Sleep for Menopausal Women

For women with vasomotor symptoms, greater leisure time activity and greater household physical activity are associated with more favorable sleep characteristics.

In-Person Recruitment Most Effective to Reach Moms-to-Be

In-person recruitment at hospital-based prenatal clinics produces the highest yield of early stage pregnant study participants.

Hormone Therapy Ups Breast Cancer Risk, Mortality

Postmenopausal hormone therapy with estrogen plus progestin is associated with an increased risk of breast cancer.

Increased Time to Pregnancy Linked to Neurological Dysfunction

Increased time to pregnancy and not fertility treatment is associated with suboptimal neurological dysfunction in 2-year-old children born to subfertile parents.

Study Examines Physician Prescription of Teen IUDs

Primary care physicians are more or less likely to prescribe long-acting reversible contraception such as intrauterine devices to adolescents based on their knowledge, skills, clinical environment, and attitudes.

Quartette Tablets Approved for Pregnancy Prevention

Quartette tablets, an extended oral contraceptive regimen, has been approved by the FDA. Made by Teva Pharmaceuticals, the tablets are designed to minimize breakthrough bleeding between scheduled periods over a 91-day oral regimen.

Viral DNA-Based Testing Can Triage Women With Abnormal Pap

DNA-based testing with Hybrid Capture 2 assay is more accurate than repeat cytology in identifying women with cervical cancer when their initial Pap smear shows atypical squamous cells of undetermined significance.

Birth Weight, Early Linear Growth Rate Affect Later Health

In low- and middle-income countries, fast linear growth in the first two years of life is associated with increased adult height and completion of more schooling, while higher weight at birth and later in childhood is associated with increased risk of obesity.

Study Redefines the 'Optimal Time for Delivery'

Around 37-38 weeks' gestation, the number of fetal deaths that could be avoided by delivery is greater than the number of neonatal deaths that would be anticipated by delivery, according to a new study.

Architect AFP Test Helps Detect Birth Defects and Progress of Testicular Cancer

The FDA has approved Abbott's Architect AFP, a test to help detect serious birth defects and the progression of testicular cancer. Alpha-fetoprotein (AFP) is a biomarker that can identify the progress of diseases or conditions as well as evaluate the effectiveness of treatments.

Urine Test for HPV Now Available

Trovagene has released a urine-based molecular human papillomavirus (HPV) test designed to identify the presence or absence of 15 known high-risk HPV strains using proprietary DNA sequences.

For Chinese Women, Age of Menarche and Menopause Linked to Cardiovascular Risk

For Chinese women, the age of menarche and menopause is not related to the risk of diabetes, but does correlate with cardiovascular disease and osteoporosis.

Grieving During Pregnancy May Increase Baby's Risk of Heart Disease

Children born to mothers who lost a close relative around the time of conception have a slightly higher risk of congenital heart disease.

No Overall Survival Benefit Tied to Bilateral Oophorectomy

At no age is there an overall survival benefit associated with bilateral oophorectomy compared with ovarian conservation at the time of hysterectomy for benign disease.

Endocrine Society Urges Better Standards for Estradiol Testing

A new position statement published by The Endocrine Society recommends that estradiol measurement assays and reference ranges be standardized and that the health care community work toward improving the accessibility of accurate estradiol testing methods.

Possible Link Between Hypospadias and High-Fat Dairy Diet During Pregnancy

Although no obvious relationship between organic diet during pregnancy and hypospadias has been found, frequent consumption of non-organic high-fat dairy products during pregnancy might be associated with increased odds of hypospadias.

No Definitive Link Between Breast Cancer Decline, Hormone Replacement

Ecological evidence does not definitively link the decline in the use of hormone replacement therapy to a fall in the incidence of breast cancer.

Factors Identified in Move from Gestational Diabetes to Type 2

For women with gestational diabetes mellitus, clinical and genetic factors including higher pre-pregnancy body mass index are associated with development of type 2 diabetes mellitus.

Robotic Hysterectomy Surgery More Expensive Without Benefit

Urging physicians to ignore the hype about robotic surgery, ACOG says the procedure, which is considerably more expensive, does not improve patient outcomes for a minimally invasive hysterectomy.

About 14% of Moms Face Postpartum Depression

About 14% of mothers are depressed postpartum, according to a new study. The most common diagnosis is major depressive disorder with comorbid anxiety disorders.

In U.S. Hospitals, Cesarean Delivery Rates Vary Widely

While the average rate was near 33%, the actual cesarean delivery rate varied from 7-70%. The rate was comparable across all hospital categories.

Study: Breastfeeding Does Not Reduce Obesity Risk for Children

While promoting breastfeeding increases breastfeeding rates, it has no effect on the risk of overweight or obesity in children. The study looked at children at a median age of 11.5 years.

Study: Global Use of Contraceptives Up, But Not for Long

Since 1990, contraceptive use has increased 8.5% worldwide, but the absolute number of women with a demand for contraception will likely increase by 6.8% by 2015, to 962 million.

Aspirin Cuts Melanoma Risk in Postmenopausal Caucasian Women

In a 12-year study with postmenopausal Caucasian women, aspirin use is associated with a significantly reduced risk of melanoma.

Link Found Between Intravaginal Insertion of OTC Products, Bacterial Vaginosis

A new study found that intravaginal insertion of over-the-counter (OTC) products increases risk of bacterial vaginosis in sexually active women, aged 18-65 years.

Prenate Chewable Vitamins Available

Avion Pharmaceuticals announced the launch of Prenate Chewable, the newest addition to the Prenate prenatal vitamin line.

Postpartum Anxiety More Common Than Depression

Postpartum anxiety is more common than depression in the days and months following delivery, and is associated with adverse maternal heath outcomes and reduced duration of breastfeeding.

ACOG Joins the Choosing Wisely Program

The American College of Obstetricians and Gynecologists (The College), in coordination with the American Board of Internal Medicine's Choosing Wisely campaign, has published the top five tests and procedures to question in obstetrics and gynecology.

Caffeine Linked to Low Birth Weight and SGA Babies

Maternal caffeine intake is associated with lower birth weight and increased odds of a baby being small for gestational age (SGA), but does not increase the risk of spontaneous preterm delivery (PTD).

Ondansetron Not Linked to Adverse Fetal Outcomes

Administration of ondansetron for treatment of nausea during pregnancy is not associated with any increased risk of adverse fetal outcomes.

Osphena Approved for Dyspareunia

Shionogi Inc. announced that the FDA has approved Osphena (ospemifene) tablets to treat women experiencing moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy due to menopause.

Infant Mortality Risk Increases With Maternal Alcohol Use

Maternal alcohol-use disorder increases the risk of both sudden infant death syndrome (SIDS) and non-SIDS-related infant mortality.

Anti-Müllerian Hormone Levels Can Predict IVF Success

A woman's plasma level of anti-Müllerian hormone (AMH), produced in the ovaries, is strongly associated with the rate of live birth after in vitro fertilization (IVF) and may serve as a prognostic factor for the chance of pregnancy and live birth.

Panorama Prenatal Screening Test To Launch

Natera announced plans to launch Panorama, a non-invasive prenatal screening test for the detection of trisomy 21 (Down syndrome), trisomy 18 (Edwards syndrome), trisomy 13 (Patau syndrome), and select sex chromosome abnormalities such as monosomy X (Turner's syndrome).

Robot-Assisted Hysterectomy Use Up From 2007-2010

The use of robotically-assisted and laparoscopic hysterectomy increased from 2007-2010; and despite similar complication rates, robotic procedures result in considerably higher costs than laparoscopic hysterectomy.

Neonatal Bisphenol A Levels Linked to Medical Device Use

The levels of bisphenol A (BPA) in the urine of premature infants in the neonatal intensive care unit is associated with greater exposure to medical devices, but not with nutritional intake.

SMFM: 17P Doesn't Prevent Preterm Labor in Twin Births

17 alpha-hydroxyprogesterone caproate (17P) is ineffective in preventing preterm delivery in women with a short cervix asymptomatically carrying twins, and may actually be harmful.

Use of Emergency Contraception Has More Than Doubled

The use of emergency contraception has more than doubled in recent years, primarily due to large increases in use by women in their early twenties.

Activated Platelets Linked to White Matter Hyperintensity

Platelet-derived thrombogenic microvesicles correlate with increased white matter hyperintensity (WMH) load in recently menopausal women.

Post-Pregnancy Deterioration in Glycemic Control in T1DM

Women with type 1 diabetes experience post-pregnancy deterioration in glycemic control and sustained weight gain.

Maternal Folic Acid Use Linked to Reduced Autism Risk

Maternal use of folic acid supplements around the time of conception is associated with a reduced risk of having children with autistic disorder.

Most Ob-Gyns Still Perform Bimanual Exam But Reasons Vary

The majority of obstetrician-gynecologists perceive bimanual pelvic examinations as important for adult women of all ages, although the reasons cited for performing the exam vary widely.

Delivery Mode, Infant Diet Affect Gut Microbiota

Mode of delivery and infant diet affect the gut microbiota early in life.

Obstetric Outcomes for Women With Asthma Evaluated

Women with asthma have significantly higher odds for nearly all obstetric complications.

CDC: Breastfeeding Increasingly Prevalent for U.S. Infants

The prevalence of breastfeeding, considered by the American Academy of Pediatrics as the normative standard for infant feeding, has grown in the United States, but in 2008, most infants were not being breastfed for the recommended 12 months.

Guidelines Updated for Young CA Survivors' Fertility Follow-Up

Current recommendations for the assessment and management of female reproductive complications following treatment of cancers in childhood, adolescence, and young adulthood have been updated.

Medroxyprogesterone Acetate Linked to Immune Suppression

Use of the injectable contraceptive depot medroxyprogesterone acetate (MPA), common in areas such as sub-Saharan Africa with high HIV-1 prevalence, is associated with suppression of the immune response.

Serum Calcium Is a Possible Biomarker of Ovarian Cancer

High serum calcium levels are associated with a greater risk of developing ovarian cancer.

Low Adiponectin in First Trimester Linked to GDM

Low adiponectin levels during the first trimester of pregnancy correlate with a higher level of insulin resistance and an increased risk of developing gestational diabetes mellitus (GDM).

United States' Premature Birth Rate Continues to Decline

The rate of premature births has declined to 11.7%, the lowest rate in a decade.

Fibroid Tumors Not Risk Factor in Twin Pregnancies

There does not appear to be an increased risk for complications in twin pregnancies with fibroid tumors compared with those without fibroid tumors.

Minivelle Estrogen Patch Now Available

Noven announced that Minivelle (estradiol transdermal system) is now available. Minivelle is indicated for the treatment of moderate to severe vasomotor symptoms (eg, hot flashes, night sweats) due to menopause.