CDC Recommends Additional Malaria Tx Option During Pregnancy

By April 12, 2018

To assess safety and efficacy of artemisinin-based combination therapies (ACTs) during pregnancy, researchers from the CDC conducted an analysis of the literature which included clinical trials, observational studies, meta-analyses and case reports conducted in Asia and Africa.

FDA Warning Ups Hysterectomy Complications for Uterine Fibroids

April 12, 2018

Among the women who underwent hysterectomy for uterine fibroids, there was a significant increase in major complications (from 1.9 to 2.4%; adjusted odds ratio, 1.23) and minor complications (from 2.7 to 3.3%; adjusted odds ratio, 1.21).

Asthma Management: During Pregnancy and Lactation

April 12, 2018

The recommendations for asthma management during pregnancy and lactation are presented in this table.

Caffeine Therapy for Apnea of Prematurity Safe Over Long Term

April 11, 2018

Compared to the placebo group, the caffeine group performed better in fine motor coordination (P=0.01), visuomotor integration (P<0.05), visual perception (P=0.02), and visuospatial organization (P=0.003).

Number of IUD Insertions Up After ACA Contraceptive Mandate

April 10, 2018

"Women in plans with the greatest reduction in out-of-pocket cost after mandated coverage of contraception had the greatest gains in IUD insertion," the authors write.

Cannabis Compound Transfers to Breast Milk

April 10, 2018

The researchers found that delta-9-tetrahydrocannabinol was detected at low concentrations at all the time points beyond time 0, but no metabolites were detected at any time point.

Prenatal Exposure to SSRI Tied to Fetal Brain Development

April 10, 2018

Compared with both healthy controls and infants exposed to untreated maternal depression, significant gray matter volume expansion was seen in the right amygdala and right insula in SSRI-exposed infants in voxel-based morphometry.

FDA Puts New Restrictions on Permanent Birth Control Implant Essure

By April 09, 2018

The new Essure labeling restricts the sale and distribution of the device to only health care providers and facilities that provide information to patients about the risks and benefits of this device.

Unintended Pregnancy Percentages by Contraceptive Method

April 06, 2018

Percentage of unintended pregnancies within first year and continued use of various contraceptive methods.

Factors ID'd for Breastfeeding Behavior in Women With BMI &#8805;30

April 06, 2018

Five factors correlated with breastfeeding behaviors: intentions to breastfeed; belief in the nutritional adequacy and sufficiency of breast milk; belief about others' infant feeding preferences; body image; and social knowledge.

Bonjesta Now Available to Treat Nausea and Vomiting of Pregnancy

By April 02, 2018

Bonjesta is a multilayer, extended-release formulation that is designed to provide both fast-acting and long-lasting symptom relief.

Infant Heart Defects May Be Early Marker of Future CVD in Mothers

April 02, 2018

There were 3.38 cardiovascular hospitalizations per 1,000 person-years for mothers with infants with critical defects, 3.19 for mothers of infants with noncritical defects, and 2.42 for mothers of infants with no heart defects.

Menopausal Hormone Therapy Linked to Reduced Abdominal Fat

March 28, 2018

No residual effect for past users, including early discontinuers of menopause hormone treatment

Complete Genome Sequence Can Be ID'd From Amniotic Fluid

March 27, 2018

The researchers found that concordance of variant calls exceeded 96% between the 2 DNA sources and with parental libraries.

Vigil Immunotherapy Tolerated Well for Recurrent Ovarian CA Tx

March 27, 2018

In the trial a personalized engineered autologous tumor cell vaccine was created incorporating rhGM-CSF DNA for enhanced antigen presentation and bifunctional shRNAfurin, which inhibits endogenous immunosuppression.

Bremelanotide NDA Submitted to FDA for Hypoactive Sexual Desire Disorder

By March 26, 2018

Bremelanotide is used as needed prior to anticipated sexual activity.

Genetic Assay of PAP Tests May Help Dx Endometrial, Ovarian CA

March 26, 2018

The researchers found that 81% of Pap brush samples from 382 endometrial cancer patients were positive, including 78% with early-stage disease. Among 245 ovarian cancer patients, sensitivity was 33%, including 34% with early-stage disease.

Challenges ID'd for Childbearing During Surgical Residency

March 26, 2018

Most women (78.4%) received maternity leave of 6 weeks or less; 72% perceived leave duration as insufficient. For 82.2% of respondents, the American Board of Surgery leave policy was cited as a major barrier to the desired length of leave.

Cimzia Label Update Provides New Information for Women of Childbearing Age

By March 22, 2018

Data added to the labeling includes first-of-their-kind pharmacokinetic studies demonstrating negligible to low transfer of CIMZIA through placenta and minimal transfer to breast milk from mother to infant.

Impact of Menopausal Hormone Tx on Cognition Assessed 3-Years Post Treatment

March 22, 2018

The longitudinal decline in dorsolateral prefrontal cortex volumes was less in the tE2 group compared with the placebo group. In the menopausal hormone therapy groups, the rates of global cognitive change did not differ from that of the placebo group.

Efficacy of Moisturizer, Estradiol Tablets Examined in Treating Vulvovaginal Symptoms

March 20, 2018

Similar reductions were seen for most bothersome symptom severity for all treatment groups over 12 weeks (estradiol, −1.4; moisturizer, −1.2; and placebo, −1.3).

Abaloparatide Followed by Alendronate Ups BMD in Postmenopausal Women

By March 19, 2018

At the 43-month endpoint, a total of 60.7% (307/506) of the abaloparatide followed by alendronate group had ≥3% increase in bone mass at all 3 sites (P<0.0001) vs. 24% (121/505) of the placebo followed by alendronate group.

Male Birth Control Pill Moves 'Step Closer' Following Safety Trial

March 19, 2018

Suppression of follicle stimulating hormone and luteinizing hormone was reported for all subjects in the P400mg group and 12 of 13 subjects in the C400mg group. No significant change was seen in mood.

Positive Results for Elagolix in Second Phase 3 Uterine Fibroid Trial

By March 14, 2018

Results - measured by the alkaline hematin method - found that at 6 months those in the combination group had 76.2% (P<0.001) clinical response compared to the elagloix along group, in which only 10.1% had a clinical response.

FDA Accepts NDA for Bio-Identical Combination Hormone Therapy

By March 09, 2018

TX-001HR is an investigational treatment for moderate-to-severe vasomotor symptoms due to menopause.

Hormone Replacement Therapies

March 06, 2018

Chart with different formulations and combination of drugs used to treat menopause.

Product Defect Leads to Recall of Hormone Replacement Therapy

By March 05, 2018

The recall was initiated due to a manufacturing defect.

Is Domperidone Effective for Increasing Breast Milk Volume?

March 05, 2018

The researchers identified 5 trials consisting of 194 women. Pooled analysis showed a moderate increase in breast milk volume of 88.3 mL/day with the use of domperidone versus placebo

Is It Safe for Women to Eat or Drink During Labor?

March 01, 2018

"Allowing women ad lib oral intake during labor does not increase adverse maternal or neonatal outcomes. It stands to reason that allowing such intake could increase patient satisfaction," the authors write.

Progestin-Only Contraceptives and Depression: Is There a Link?

By February 28, 2018

Study quality was graded according to the United States Preventive Services Task Force and the Cochrane Risk of Bias Tools.