Pfizer announced top-line results from OCTAVE Sustain, the third Phase 3 study of Xeljanz (tofacitinib citrate) for the potential treatment of patients with moderately to severely active ulcerative colitis (UC).
Treatment with ferumoxytol for patients with iron deficiency anemia (IDA) and comorbid gastrointestinal disorders was found to be efficacious and generally well-tolerated in an analysis of a Phase 3 trial.
St. John's wort has been used as an herbal remedy for over 100 years, but how does it compare to conventional SSRIs for the treatment of depression?
The FDA has granted Fast Track designation to SHP626 (volixibat; Shire) for the potential treatment of nonalcoholic steatohepatitis (NASH) with liver fibrosis
Habitual nut consumption was associated with a healthy profile of inflammatory biomarkers, researchers from Brigham and Women's Hospital and Harvard Medical School reported.
New research suggests that in the United States, a third of esophageal cancer cases - about 5,600 per year - could be prevented if people maintained a healthy weight and didn't drink.
For patients in the Apixaban for Reduction of Stroke and Other Thromboembolic Complications in Atrial Fibrillation (ARISTOTLE) trial, the 5 mg twice daily dose of apixaban is beneficial and appropriate for those with one dose-reduction criterion, according to a study published online in JAMA Cardiology.
Recro Pharma announced positive results from the Phase 3 study for intravenous (IV) meloxicam (N1539) for the treatment of acute postoperative pain in patients following bunionectomy surgery.
Teen smoking rates have declined in the last 2 decades, however health complaints from those who remain smokers have risen, according to findings from a new analysis of the Health Behavior in School-aged Children survey.
A study in The Journal of Pain found that the inability to manage negative emotional and somatic stress is tied to opioid misuse in adults with chronic pain.
The FDA has granted Fast Track designation to Caladrius Biosciences' product candidate CLBS03 (autologous expanded polyclonal regulatory T cells, or Tregs) for the treatment of Type 1 diabetes mellitus (T1DM).
Teens with easy access to drugs and alcohol at home are more likely to drink and abuse drugs in adulthood, researchers from the Michigan State University reported.
Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) use were not associated with an increased risk of seizures, in the general population and in those with epilepsy, according to a new observational study.
Clinicians should suspect coccidioidomycosis, also known as San Joaquin Valley fever, in patients with pneumonia or ongoing flu-like symptoms who live in or have visited the west or southwest United States, especially Arizona and central California, according to updated guidelines from the Infectious Diseases Society of America (IDSA) published online in Clinical Infectious Diseases.
Florida health officials are investigating two more unexplained cases of Zika infection, bringing to four the number of cases that don't seem to be related to travel to countries where the virus is circulating.
Deep brain stimulation (DBS) appears safe for patients with early Alzheimer's disease (AD) -- and might even slow down memory loss in some, according to a preliminary study published online July 18 in the Journal of Alzheimer's Disease.
The Centers for Disease Control and Prevention (CDC) released an update to the 2013 U.S. Selected Practice Recommendations for Contraceptive Use guideline after review of scientific data and expert consultation.
In certain scenarios a third dose of the measles-mumps-rubella (MMR) vaccine may be considered a control measure against mumps, when transmission is sustained despite high 2-dose MMR coverage, say the Centers for Disease Control and Prevention (CDC).
A recent Morbidity and Mortality Weekly Report (MMWR) found increasing use of kratom (mitragyna speciosa) in the United States with medical outcomes and health effects suggesting an "emerging public health threat."
Arbor announced a Class II drug recall of three lots of Cetylev (acetylcysteine) effervescent tablets for oral solution due to possible degradation of the effervescent tablets.
Assessment with nonvascular thoracic magnetic resonance (MR) imaging improves clinical decision making, according to a study published in the August issue of Radiology.
Dutch researchers are reporting a case of miscarriage tied to maternal infection with the Zika virus. The report was published online July 27 in the New England Journal of Medicine.
Potential new asthma genes have been identified in a genome-wide association study (GWAS) combined with subsequent lung expression quantitative trait loci (eQTL) analysis, according to research published in Allergy.
For patients with metastatic melanoma, the addition of local peripheral treatments (LPT) such as radiotherapy or electrochemotherapy is beneficial, according to a study published online in Cancer Immunology Research.
In an experimental study published online in the Journal of the American Heart Association, lab rats experienced substantially impaired endothelial function after a minute's exposure to secondhand smoke (SHS) from marijuana.
Sanofi announced that the Food and Drug Administration (FDA) has approve Adlyxin (lixisenatide) injection as an adjunct to diet and exercise for the treatment of adults with type 2 diabetes.
The hugely popular "Ice Bucket Challenge" funded a study that has discovered an important new amyotrophic lateral sclerosis (ALS) gene. The study, which involved more than 80 researchers in 11 countries, was published online July 25 in Nature Genetics.
Poor physical fitness ranks right behind smoking as leading risk factors for early mortality, according to a study published online the European Journal of Preventive Cardiology.
Being transgender is currently classified as a mental health disorder in the World Health Organization International Classification of Diseases, but a new study, published online in The Lancet Psychiatry, suggests that should change.
The FDA has granted Breakthrough Therapy designation to Darzalex (daratumumab; Janssen Biotech) in combination with lenalidomide and dexamethasone, or bortezomib and dexamethasone, for the treatment of multiple myeloma in patients who have received at least one prior therapy.
A retrospective cohort study in the Annals of Pharmacotherapy found a clinically significant decrease in warfarin dose-response with concurrent hepatitis C treatments, especially with ombitasvir/paritaprevir/ritonavir and dasabuvir (OBV-PTV/r-DSV).
For pancreatic ductal adenocarcinoma (PDAC) patients with diabetes, metformin treatment was associated with an increase in survival. Those were the findings of a new study published in the American Journal of Gastroenterology.
TauRx Therapeutics announced findings from the Phase 3 trial of LMTX for the treatment of mild or moderate Alzheimer's disease (AD). Results were presented at the 2016 Alzheimer's Association International Conference (AAIC) in Toronto, Canada.
Split-dose (SPD) bowel preparation regimen led to reduced intensity and duration of bowel movements as well as less patient inconvenience, improved bowel preparation, and increased sessile-serrated poly detection rates, compared with a single-dose (SID) preparation, study authors reported in the American Journal of Gastroenterology.
Alzheimer's disease is often misdiagnosed, possibly more so in men, two new studies reveal. The results of both studies were presented at the annual Alzheimer's Association International Conference, held from July 22 to 28 in Toronto.
The average delay to diagnosis of bipolar disorder is six years, according to a review published online July 26 in the Canadian Journal of Psychiatry.
For pediatric patients with migraine, biofeedback seems to be an effective intervention, according to a review published online July 26 in Pediatrics.
The American Red Cross says it has an urgent need for blood donations, with less than a five-day supply of blood on hand to help those who need it.
There is insufficient evidence to recommend regular full-body exams for skin cancer as a means of preventing deaths from these cancers, according to a new review and recommendation statement published in the Journal of the American Medical Association.
Obstetrician-gynecologists should counsel pregnant women about use of long-acting reversible contraception (LARC), such as implants and intrauterine devices (IUDs), immediately after they give birth, according to an American College of Obstetricians and Gynecologists (ACOG) Committee Opinion published in Obstetrics & Gynecology.
The odds of surviving a stroke are slightly better for patients treated at hospitals with primary stroke centers (PSCs), but only if stroke patients get to the center in less than 90 minutes, according to research published online in JAMA Internal Medicine.
Younger women who exercise just 2.5 hours a week may cut their risk for coronary heart disease (CHD) by up to 25%, according to research published in the July 26 issue of Circulation.
The European League Against Rheumatism (EULAR) have updated their recommendations on the management of gout to reflect novel treatments and evidence surrounding already established treatments.
A bracelet that can track a woman's fertility has been launched today by the medical technology company Ava. In clinical trials the bracelet (which is worn only at night), detected an average of 5.3 fertile days per cycle with 89% accuracy.
Although evidence is limited, a new systematic review in Contraception indicates a greater risk of ovulation and breakthrough as well as reduced contraceptive efficacy when combined oral contraceptives (COCs) are co-administered with St. John's wort.
AbbVie announced that the Food and Drug Administration (FDA) has approved a New Drug Application (NDA) for Viekira XR (dasabuvir, ombitasvir, paritaprevir, ritonavir) extended-release tablets.
Inducing labor won't raise a pregnant woman's risk of having a child with autism, according to a study published online JAMA Pediatrics.
In 2014, Colorado and Washington became the first two states to legalize recreational marijuana. Shortly after, a sharp increase occurred in the number of Colorado children younger than 10 who became ill after being exposed to marijuana, according to a study published online in JAMA Pediatrics.
From 2011 to 2014 there were increases in the rate of hepatitis C virus (HCV) detection among women of childbearing age, according to research published in the July 25 early-release issue of the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.
Up to 1.6 million childbearing women in Central and South America may be at risk for infection with the Zika virus by the end of the first phase of the epidemic, according to a letter published online July 25 in Nature Microbiology.
U.S. health officials on Monday updated their Zika virus guidelines, saying that pregnant women could contract Zika from a sex partner of either gender.
People who work in jobs that task the intellect are better able to withstand the effects of brain lesions commonly associated with Alzheimer's disease, report researchers from the University of Wisconsin's Alzheimer's Disease Research Center.
Delirium is fairly common, yet often missed, in advanced cancer patients who visit emergency departments, according to a study published online in Cancer.
Certain behavior changes may be a harbinger of Alzheimer's disease, and researchers say they've developed a symptom checklist that might aid earlier diagnosis. The findings were presented at the annual Alzheimer's Association International Conference, held from in Toronto.
According to a study in The American Journal of Drug and Alcohol Abuse, psilocybin showed promise in promoting long-term smoking abstinence in the context of a structured treatment program.
A new study has deemed that concern for clinically significant drug interactions between hormonal contraceptives (HC) and psychotropic drugs is low; however, the authors of the study did assert that more research is needed in this area.
Among patients with cancer, researchers found a high prevalence of non-adherence to oral antidiabetic medications and negative consequences tied with non-adherence.
The FDA has issued a Complete Response Letter (CRL) to the New Drug Application (NDA) of Dextenza (dexamethasone insert; Ocular Therapeutix) 0.4mg for the intracanalicular treatment of ocular pain after ophthalmic surgery.
Statin users who used a drug coupon for their first fill, were significantly less likely to terminate their therapy than non-coupon users. Those were the findings of a new retrospective study spanning 7 years, published in the journal Pharmacotherapy.
An analysis published in Medicine identified hip-joint lesion, prevalence of peripheral arthritis, and antistreptolysin O (ASO) and circulating immune complex (CIC) levels as risk factors that may be tied to higher rates of uveitis in ankylosing spondylitis.
Merck announced that the Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to the investigational vaccine V920 (rVSV-ZEBOV-GP, live attenuated) for the Ebola Zaire virus.
An injectable fluocinolone acetonide long-acting implant may be able to effectively control intraocular inflammation, as well as improve visual acuity, in patients with a history of recurrent noninfectious intermediate uveitis, posterior uveitis, or panuveitis.
An ultrasonographically (US)-guided percutaneous treatment using a 21-gauge needle is efficacious for trigger finger, according to a study published in the August issue of Radiology.
For patients with type 1 diabetes mellitus (T1DM), severe hypoglycemia is associated with increased risk of all-cause mortality and cardiovascular disease (CVD), according to research published online July 6 in Diabetes Care.
Starting patients on an optimal antiretroviral (ART) regimen from the start reduces the need for switching, and may positively impact patients and healthcare systems overall, a study published in the Annals of Pharmacotherapy reported.
Sunovion announced positive findings from the GOLDEN-5 safety study evaluating SUN-101 (glycopyrrolate) delivered via an investigational nebulizer system (SUN-101/eFlow) for the treatment of moderate-to-very severe chronic obstructive pulmonary disease (COPD).
Andrew Chan, M.D., of Massachusetts General Hospital in Boston, and colleagues tracked data on 1,659 patients diagnosed with CRC.
Botulinum toxin A (BTA) alleviated the severity and frequency of chronic daily headache and improved depression and anxiety, a study in the International Journal of Neuroscience found.
Gilead announced that two Phase 3b switch studies evaluating Odefsey (emtricitabine, rilpivirine, tenofovir alafenamide) for the treatment of HIV-1 infection met their primary objectives.
Amgen and UCB announced the submission of a Biologics License Application (BLA) to the Food and Drug Administration (FDA) for romosozumab for the treatment of osteoporosis in postmenopausal women at increased risk of fracture.
Zydus announced a voluntary recall of Venlafaxine HCl ER 75mg and 150mg Capsules due to an out of specification dissolution result in a retained sample.
GlaxoSmithKline announced a recall of 13 lots of Bactroban (mupirocin) Nasal Ointment, Bactroban Ointment, and Bactroban Cream. This recall is a precautionary measure due to potential contamination during manufacturing.
The U.S. prescription drug abuse epidemic has increased the risk of HIV outbreaks in rural and suburban communities, where up to now the virus has posed little threat, according to a report published in the New England Journal of Medicine.
Varicocele embolization has a high rate of technical success, with the results being the same regardless of whether the procedure is performed through the neck or groin, according to a study published online July 11 in the Journal of Medical Imaging and Radiation Oncology.
Nebulized fentanyl is as effective as IV opioids for the treatment of acute pain, however the variations of prepared fentanyl nebulized solution leave a question mark over the ability to deliver consistent doses.
Nanohealth announced the launch of the nanopause Bolero, a non-hormone product cleared by the Food and Drug Administration (FDA) to relieve symptoms of menopause such as hot flashes and night sweats.
An analysis published in International Clinical Psychopharmacology found that paliperidone palmitate once-monthly (PP1M) had a more favorable benefit-risk profile compared to oral paliperidone extended-release (ER) in the maintenance treatment of schizophrenia through Week 40.
Teduglutide (Gattex; NPS Pharmaceuticals) appeared safe and effective in patients with Crohn's disease with short bowel syndrome requiring parenteral support, a study published in the Journal of Clinical Gastroenterology reported.
An experimental drug spurred substantial weight loss in patients with proopiomelanocortin (POMC) deficiency, according to a study published in the July 21 issue of the New England Journal of Medicine.
About one-third of Princeton University students given a vaccine to combat a meningitis B outbreak on campus in 2013 didn't show signs of protection against the infection eight weeks later, according to a study published in the New England Journal of Medicine.
Improvement in cognitive ability is not associated with estrogen therapy among women who use it after menopause, no matter when they start taking it, according to a study published online in Neurology.
Progress has been made toward developing lab-grown cartilage that could postpone or possibly eliminate the need for hip replacement surgery in younger arthritis patients, according to research published online in the Proceedings of the National Academy of Sciences.
More American teens have diabetes or prediabetes than previously thought, and many don't know they have the condition, according to a research letter published in the Journal of the American Medical Association.
The number of practicing psychiatrists declined from 2003 to 2013, while the number of physicians in other disciplines grew, according to a report published in the July issue of Health Affairs.