Intra-Cellular Therapies have announced inconclusive results from the second Phase 3 trial of ITI-007 (Study '302), a first-in-class investigational medicine for the treatment of schizophrenia.
Older adults with questionable cognitive impairment exposed to anticholinergics demonstrated higher global cognitive scores compared to those not exposed to anticholinergics, according to a study published in Drugs & Aging.
Vertex announced that the Food and Drug Administration (FDA) has approved Orkambi (lumacaftor and ivacaftor) tablets for use in children with cystic fibrosis aged 6-11 years who have 2 copies of the F508del mutation.
A systematic review and meta-analysis published in the journal International Clinical Psychopharmacology found that pregabalin was superior to placebo for the amelioration of generalized anxiety disorder (GAD) symptoms.
Amgen announced positive top-line results from their Phase 3 trial ARISE, evaluating erenumab (AMG 334) for safety and efficacy in preventing migraines.
AstraZeneca announced that the Food and Drug Administration (FDA) has approved cobas EGFR Mutation Test v2, a companion diagnostic for Tagrisso (osimertinib).
A study published in Neurology found that the majority of patients with Lennox-Gastaut syndrome do not develop tolerance to the antiseizure effects of clobazam (Onfi).
Lubiprostone was significantly more effective in improving abdominal pain or bloating than placebo, according to results from a post-hoc analysis published in Alimentary Pharmacology and Therapeutics.
Researchers from the St. Louis University School of Medicine report that adjunctive N-acetylcysteine (NAC) may be effective in reducing negative and general symptoms in schizophrenia.
Constitutional symptoms, including mentation, often lead to diagnostic testing and potentially inappropriate antibiotic prescribing in older patients suspected of having a urinary tract infection (UTI) or pneumonia, according to a study published online in the Journal of the American Geriatrics Society.
Among men with intermediate-risk prostate cancer, the addition of external beam therapy (EBT) to transperineal interstitial permanent brachytherapy (B) does not improve five-year progression-free survival.
For women with cervical and endometrial cancer, treatment with intensity-modulated radiation therapy (IMRT) is associated with reduced toxicity.
For patients with mild-to-moderate psoriasis, adherence to topical treatment is low, but an internet-based reporting intervention can improve adherence.
The MiniMed 670G hybrid closed looped system, referred to as an "artificial pancreas" adjusts insulin levels with little or no interaction from the user.
The new CGM system provides healthcare professionals with a patient's ambulatory glucose profile (AGP), showing a clearer overview of glucose levels, patterns, and trends.
Treatments other than statins also can effectively reduce cardiovascular risk, according to a review and meta-analysis published in the Journal of the American Medical Association.
Regeneron and Sanofi announced that the Food and Drug Administration (FDA) has accepted for priority review the Biologics License Application (BLA) for dupilumab for the treatment of adults with inadequately controlled moderate-to-severe atopic dermatitis (AD).
AcelRx has announced the initiation of the Phase 3 IAP312 study of Zalviso (sufentanil sublingual tablet system), an investigational treatment for the management of moderate-to-severe acute pain in adult patients.
Insomnia-specific treatment proved effective at improving daytime and psychological functioning in the short-term, and maintenance therapy added further value to optimizing long-term outcomes, according to a study published in Behaviour Research and Therapy.
Biogen and Ionis have completed the rolling submission of a New Drug Application (NDA) to the FDA for the approval of nusinersen, an invesigational treatment for spinal muscular atrophy (SMA), for which there is currently no approved treatment.
Eisai announced the submission of a supplemental application for a proposed label change for Fycompa (perampanel) which would include use as monotherapy for the treatment of partial-onset seizures (POS) with or without secondarily generalized seizures in patients with epilepsy ≥12 years.
Kratom, a plant indigenous to Southeast Asia, is used by individuals for its stimulant effects and as an opioid substitute, but because of its uncertain and inconsistent purity levels and quantities, the drug can pose significant health risks to users.
Summit Therapeutics announced it has received a Fast Track designation from the Food and Drug Administration (FDA) for Ezutromid in the treatment of Duchenne muscular dystrophy (DMD).
Cambrooke Therapeutics announced the launch of Tylactin RESTORE Powder, a new medical hydration beverage for the dietary management of tyrosinemia.
Espero announced the launch of GoNitro (nitroglycerin) sublingual powder for acute relief of an attack or prophylaxis of angina pectoris due to coronary artery disease.
Visceral adipose tissue - particularly in the abdominal region - may indicate increased risk for cardiovascular disease, and lower fat density may equal higher risk, according to a study published in the Journal of the American College of Cardiology.
In young Faroese adults, aerobic fitness is associated with short-term memory and processing speed, and the correlation is attenuated by prenatal methylmercury exposure, according to a study published in Environmental Health Perspectives.
In patients with coronary artery disease (CAD), achievement of optimal medical therapy (OMT) before implantation of a drug-eluting stent significantly reduces subsequent cardiac events
The Centers for Disease Control and Prevention (CDC) suggest that doctors evaluate patients who report penicillin allergy for true allergy.
Noninfectious uveitis (NIU) is more prevalent among female than male adults and the number of cases increase in tandem with age. These are the findings of a new study published in JAMA Ophthalmology that focused specifically on noninfectious uveitis prevalence.
Over 90% of U.S. high school students don't get enough moderate-to-vigorous exercise, and the pattern persists after they graduate, according to a study published online September 26 in Pediatrics.
There seems to be a trend toward increased HIV testing and earlier HIV diagnosis among men who have sex with men (MSM), according to a report published in the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.
Empathetic listening can help physicians navigate difficult situations and forge deeper connections with patients, leading to greater professional satisfaction and joy, according to the American Medical Association.
Array BioPharma and Pierre Fabre announced top-line data from part 1 of the Phase 3 COLUMBUS study evaluating LGX818 (encorafenib) and MEK162 (binimetinib) in patients with BRAF-mutant advanced, unresectable or metastatic melanoma.
The Food and Drug Administration has granted Fast Track status to Axovant Sciences for their investigational New Drug application for intepirdine for the treatment of dementia with Lewy bodies.
GW Pharmaceuticals announced positive data from the second randomized, double-blind, placebo-controlled Phase 3 trial of Epidiolex (cannabidiol) for the treatment of seizures associated with Lennox-Gastaut syndrome (LGS).
The FDA has approved the supplemental New Drug Application (sNDA) for Brilinta (Ticagrelor; AstraZeneca) for an addition to the label under the Warnings and Precautions concerning bradyarrhythmias.
Janssen announced the submission of a supplemental New Drug Application (sNDA) for Imbruvica (ibrutinib; Janssen and Pharmacyclics) for the treatment of patients with marginal zone lymphoma (MZL) who require systemic therapy.
For patients with inadequately controlled, basal insulin-treated type 2 diabetes, a novel, titratable, fixed-ratio combination of insulin glargine (iGlar) and lixisenatide (iGlarLixi) is associated with improvements in glycemic control and reduced body weight.
Cumberland announced the relaunch of Ethyol (amifostine) for Injection indicated to reduce the incidence of xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer, and to reduce the cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer.
Otsuka and Lundbeck announced that the Food and Drug Administration (FDA) has approved the labeling update for Rexulti (brexpiprazole) to reflect clinical data for maintenance treatment of schizophrenia.
Janssen Biotech announced that the Food and Drug Administration (FDA) has approved Stelara (ustekinumab) for the treatment of moderately to severely active Crohn's disease in adult patients.
The thousands of miles of aging, corroding pipes that bring water to Americans each day may be home to drug-resistant bacteria, according to a report published online September 12 in the Journal of Public Health Policy.
Patients with tinnitus may find some immediate relief with nasally-administered oxytocin, according to a study presented at the annual meeting of the American Academy of Otolaryngology-Head and Neck Surgery.
The Food and Drug Administration (FDA) has approved Amjevita (adalimumab-atto; Amgen) as a biosimilar to Humira (adalimumab; AbbVie) for various inflammatory diseases.
The Food and Drug Administration (FDA) has granted three approvals for the expanded use of Ilaris (canakinumab; Novartis) for patients with rare Periodic Fever Syndrome conditions.
The seroprotection rate of the hepatitis B and measles vaccines was reduced in some diabetic children, according to a new study published in the Journal of Pediatric Endocrinology and Metabolism.
or patients with gastric adenoma or early gastric cancer, standard dose or double dose intravenous pantoprazole for 48 hours is equally effective for prevention of delayed bleeding after endoscopic resection, according to a study published online in the Journal of Gastroenterology and Hepatology.
In germ cell tumors (GCTs), TP53 and MDM2 alterations correlate with cisplatin resistance and are associated with inferior outcome, according to a study published online September 19 in the Journal of Clinical Oncology.
Pregabalin is beneficial for neuropathic pain, regardless of previous gabapentin use, according to research published online September 9 in Pain Practice.
The Food and Drug Administration (FDA) has approved Epaned (enalapril maleate; Silvergate Pharmaceuticals) Oral Solution for the treatment of hypertension in adults and children >1 month.
Janssen Biotech announced the submission of a Biologics License Application (BLA) to the Food and Drug Administration (FDA) for the approval of sirukumab for the treatment of adults with moderately to severely active rheumatoid arthritis (RA).
Parkinson's disease (PD) patients with glucocerebrosidase gene (GBA) mutations have increased risk for dementia and death, according to a study published online in the Annals of Neurology.
Falls are the leading cause of injury and death among older people in the United States, according to research published in the U.S. Centers for Disease Control and Prevention's Morbidity and Mortality Weekly Report.
An experimental DNA-based vaccine for Zika virus has proceeded to human safety trials, according to findings published online in 'Science'.
A drug used for rheumatoid arthritis might regrow hair in alopecia areata (AA) patients, according to a study published online September 22 in JCI Insight.
Based on long-term clinical outcomes in patients with inflammatory bowel disease (IBD), the benefits of sequentially added combination therapy appear diminished.
The Food and Drug Administration (FDA) has granted Fast Track designation to Sanaria PfSPZ Vaccine, a preventative vaccine for malaria.
Allergan and Adamas announced that all 4 dosage strengths of Namzaric (memantine and donepezil HCl) extended-release capsules are now available for the treatment of moderate to severe Alzheimer's disease in patients stabilized on 10mg of donepezil HCl once daily.
An experimental drug, laquinimod, appears to prevent or slow the progression of multiple sclerosis (MS) in mice, according to a study published online in Neurology: Neuroimmunology & Neuroinflammation.
A new type of immunotherapy involving natural killer (NK) cells may help treat acute myeloid leukemia (AML) patients, according to a study published in the Science Translational Medicine.
For preterm infants with early respiratory distress, high-flow therapy used as primary support is associated with a higher rate of treatment failure than continuous positive airway pressure (CPAP), according to a study published in the New England Journal of Medicine.
In obese patients, changes in blood microbiota are associated with liver fibrosis, according to a study published online in Hepatology.
Congenital brain abnormalities are similar for confirmed and presumed Zika infections, according to a study published in the October issue of Radiology.
Patients who have an organ transplant may be more likely to develop skin cancer, and that applies to all transplant patients, even those who are nonwhite and dark-skinned, according to research published online Sept. 21 in JAMA Dermatology.
Smoking cigarettes can leave a lasting imprint on human DNA, altering more than 7,000 genes in ways that may contribute to the development of smoking-related diseases, according to research published online in Circulation: Cardiovascular Genetics.
An overall lack of quality evidence exists for the use of topical analgesics and anesthetics (creams, gels and patches) as a therapeutic method for treating chronic pain, according to a new review published in the journal Dermatitis.
The FDA has approved the supplemental New Drug Application (sNDA) for Savaysa (edoxaban tosylate; Daiichi Sankyo) that provides for changes to the labeling based on a trial that evaluated the effects of Prothrombin Complex Concentrate (PCCs) on reversing the pharmacological activity of the drug.
The Food and Drug Administration (FDA) has approved several changes to the prescribing information for Plavix (clopidogrel bisulfate tablets; Bristol-Myers Squibb and Sanofi).
An Opinion Statement published in Current Treatment Options in Psychiatry concluded that based on current data, selective serotonin reuptake inhibitors (SSRIs) and and selective serotonin norepinephrine reuptake inhibitors (SSNRIs) are effective in the treatment of pediatric anxiety disorders in addition to some forms of psychotherapy (eg, cognitive-behavioral therapy [CBT]).
Antimicrobial resistance (AMR) remains a major public health threat, and only a multipronged attack can address the problem, according to a report published in the September 20 issue of the Journal of the American Medical Association.
Stressful events from the day before appear to eradicate any health benefits a person might have gained from choosing a breakfast rich in monounsaturated fats
More Americans are benefiting from immunotherapy, according to the sixth annual American Association for Cancer Research (AACR) Cancer Progress Report.
Obese children and adolescents have different gut flora composition than their normal-weight peers, according to a study published online September 20 in the Journal of Clinical Endocrinology & Metabolism.
A non-tumor necrosis factor (TNF)-targeted biologic is more effective than a second anti-TNF drug for treatment of rheumatoid arthritis in patients with insufficient response to a first anti-TNF drug
For buprenorphine prescribers, the monthly patient census is 13 patients, according to a research letter published in the September 20 issue of the Journal of the American Medical Association.
For women with type 1 diabetes, elevated fatty acid binding protein 4 (FABP4) in early pregnancy and in the second trimester is associated with subsequent preeclampsia, according to a study published online September 14 in Diabetes Care.
Janssen announced that the Food and Drug Administration (FDA) has approved Invokamet XR (canagliflozin, metformin HCl extended-release) for first-line use as an adjunct to diet and exercise to improve blood glucose control in adults with type 2 diabetes when treatment with the two medications is appropriate.
Early introduction of egg and peanuts could help prevent 24 cases of egg allergy per 1,000 people and 18 cases of peanut allergy per 1,000 people, according to research published in the September 20 issue of the Journal of the American Medical Association.
Another mosquito-borne virus may be starting to circulate in the Caribbean, according to findings published online recently in the U.S. Centers for Disease Control and Prevention's Emerging Infectious Diseases.
The vaccine against the H1N1 strain of influenza doesn't appear to be linked to congenital malformations, according to research published online in the Annals of Internal Medicine.