NORPACE-CR Rx

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NORPACE-CR

CHF and arrhythmias
Only 4 drugs may be compared at once

Generic Name and Formulations:

Disopyramide (as phosphate) 100mg, 150mg; controlled-release caps.

Company:

Pfizer Inc.

Select therapeutic use:

Indications for NORPACE-CR:

Documented life-threatening ventricular arrhythmias.

Adult:

200–400mg every 12hrs.

Children:

Use immediate-release caps.

Contraindications:

Cardiogenic shock. 2nd- or 3rd- degree AV block, unless paced. Congenital QT prolongation. Severe renal insufficiency (CrCl ≤40mL/min): CR form not recommended.

Warnings/Precautions:

Correct potassium imbalance before starting. Discontinue if hypotension or CHF worsening occurs; if needed, restart at lower dose after cardiac compensation established. Reduce dose in 1st-degree AV block, consider discontinuing if persistent. Monitor closely or discontinue if QT prolongation or QRS widening occurs. Atrial tachyarrhythmias: digitalize first. Conduction defects. Cardiomyopathy. Renal or hepatic dysfunction. Urinary retention. BPH. Glaucoma. Myasthenia gravis. Chronic malnutrition. Elderly. Labor & delivery. Pregnancy (Cat.C): may stimulate uterine contractions. Nursing mothers: not recommended.

Interactions:

Avoid other antiarrhythmics except in unresponsive, life-threatening arrhythmias. Avoid CYP3A4 inhibitors (eg, erythromycin, clarithromycin); may result in fatal interactions. Hypoglycemia with β-blockers, alcohol. Antagonized by hepatic enzyme inducers (eg, phenytoin). Do not give within 48hrs before or 24hrs after verapamil.

See Also:

NORPACE

Pharmacological Class:

Class I antiarrhythmic.

Adverse Reactions:

Anticholinergic effects (eg, dry mouth, urinary retention, constipation, blurred vision), GI upset, dizziness, fatigue, impotence, hypotension, heart failure, AV block, edema, rash, hypoglycemia, hypokalemia, jaundice, blood dyscrasias, lupus-like syndrome, psychosis.

How Supplied:

Caps—100; CR—100, 500

NORPACE-CR 100mg capsules (Qty:120)

appx. price $458.00