Compare
NORDITROPIN FLEXPRO PEN to:
Generic Name for NORDITROPIN FLEXPRO PEN
Somatropin (rDNA origin) 5mg, 10mg, 15mg; per 1.5mL prefilled pen; soln for SC inj.
Legal Classification:
Rx
Pharmacological Class for NORDITROPIN FLEXPRO PEN
Growth hormone (GH).
Manufacturer of NORDITROPIN FLEXPRO PEN
Novo Nordisk
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Indications for NORDITROPIN FLEXPRO PEN
Growth failure in children due to inadequate endogenous GH secretion. Children with short stature associated with Noonan or Turner syndrome. Children with short stature born small for gestational age (SGA) with no catch-up growth by age 2–4yrs. Adults with childhood-onset or adult-onset GH deficiency.
Adult dose for NORDITROPIN FLEXPRO PEN
Inject SC; rotate sites. Weight-based: Initially up to max 0.004mg/kg per day; may increase after 6 weeks to max 0.016mg/kg per day. Non-weight based: approx. 0.2mg/day (range: 0.15–0.3mg/day), may increase gradually every 1–2 months by increments of approx. 0.1–0.2mg/day.
Children's dosing for NORDITROPIN FLEXPRO PEN
Inject SC; rotate sites. Individualize. GH deficient: 0.024–0.034mg/kg per day, 6–7 times/week. Short stature w. Noonan: up to 0.066mg/kg per day. Short stature w. Turner or SGA: up to 0.067mg/kg per day.
Also:
Contraindications for NORDITROPIN FLEXPRO PEN
Acute critical illness. Acute respiratory failure. Closed epiphyses. Active malignancy or growing intracranial tumors. Diabetic retinopathy. Prader-Willi syndrome (severely obese or w. respiratory impairment); see literature.
Warnings/Precautions for NORDITROPIN FLEXPRO PEN
Monitor gait, thyroid function, glucose tolerance, for malignant transformation of skin lesions, and for intracranial hypertension (do baseline and periodic funduscopic exams). History of intracranial lesions: monitor for lesion progression or recurrence. Prader-Willi syndrome: evaluate baseline respiratory function; monitor weight and for respiratory infection. Discontinue if signs of upper airway obstruction or sleep apnea occurs. Diabetes. Hypothyroidism. Scoliosis. Turner syndrome: evaluate for ear disorders (eg, otitis media); monitor for cardiovascular disorders (eg, stroke, aortic aneurysm/dissection, hypertension). Pregnancy (Cat.C). Nursing mothers.
Interactions for NORDITROPIN FLEXPRO PEN
Antagonized by glucocorticoids. Antidiabetic medications may need to be adjusted. May affect CYP3A4 substrates. Women on oral estrogen: may need higher somatropin dose.
Adverse Reactions for NORDITROPIN FLEXPRO PEN
Headache, inj site reactions, localized muscle pain, weakness, hypothyroidism, mild hyperglycemia, glucosuria, arthralgia, myalgia, fluid retention, edema, elevated serum phosphate, antibody formation, pancreatitis; also children: slipped capital femoral epiphysis. Long-term overdose may cause gigantism and/or acromegaly.
How is NORDITROPIN FLEXPRO PEN supplied?
Cartridges 5mg, 15mg—1 (use w. NordiPen device)
FlexPro prefilled pen—1
NordiFlex prefilled pen—1