Nonnarcotic Analgesics

Clinicians Increasingly Prescribing Gabapentinoids to Avoid Opioids

August 03, 2017

Gabapentinoids are increasingly being used for almost any type of pain. U.S. prescribing data support this, with gabapentin being the 10th most commonly prescribed medication in 2016.

'Smart' Undergarment Helps Reduce Stress on the Lower Back

By August 02, 2017

When wearing the clothing lower back activity was reduced by an average of 15 to 45%.

Aspirin-Induced Platelet Inhibition May Be More Potent Post-Bariatric Sx

July 20, 2017

The researchers found that off-treatment ARU was significantly reduced post-bariatric surgery versus pre-surgery levels (602±59 versus 531±78; P=0.035).

Treatments Compared for Managing Musculoskeletal Pain in Primary Care

By June 27, 2017

In general, the best available evidence pointed to self-management advice, exercise therapy and psychosocial interventions as effective strategies for managing musculoskeletal pain in primary care.

From Treatment to Training: 5 Uses of Virtual Reality in Healthcare

June 27, 2017

Virtual reality is much more than just a new form of entertainment, it is increasingly being used in a wide range of medical applications.

Analgesic Effects of Gabapentin Assessed in Chronic Neuropathic Pain

By June 26, 2017

Their findings demonstrated that 3 or 4 out of 10 participants achieved this degree of pain relief with gabapentin, vs. 1 or 2 out of 10 for placebo.

NSAID Use May Benefit Certain Colorectal Cancer Survivors

June 20, 2017

The researchers administered detailed epidemiologic questionnaires to 2,419 patients age 18 to 74 years with incident invasive CRC, diagnosed from 1997 to 2008.

Could Acupuncture Be an Effective Alternative to Pain Meds in the ER?

June 20, 2017

The study - billed as the world's largest randomized, controlled trial of acupuncture in the emergency department - included 528 patients.

First-in-Class Drug Candidate Fast Tracked for Chronic Pain

By June 14, 2017

Currently, there is a global Phase 3 program comprised of 6 studies involving approximately 7,000 patients with OA, CLBP or cancer pain with inadequate treatment of pain with approved therapies.

Can Olive Oil Enhance the Therapeutic Effect of Ibuprofen?

June 13, 2017

Compared with the 2 compounds used separately, the combination of EVOO and ibuprofen at its therapeutic dose showed superiority.

Can IV Acetaminophen Reduce Post-Op Pain in Sinus Sx?

May 26, 2017

The results showed immediate relieve for the treatment group but as time went on the placebo group actually showed greater meaningful reductions in pain.

Law Enforcement Data Indicate a Rise in Gabapentin Misuse

By May 15, 2017

Using data from the Drug Diversion Program of the Researched Abuse, Diversion, and Addiction-Related Surveillance System, the authors were able to calculate the rates of gabapentin diversion (per 100,000 population) for each quarter from 2002-2015

NSAIDs May Up MI Risk Within the First Week of Use

By May 10, 2017

Drug dose, duration of use, and recency of use were all evaluated.

Managing Abdominal Pain in IBD: A Review

By May 09, 2017

Researchers analyzed 13 intervention studies which evaluated various psychological, dietary, and drug interventions.

Acetaminophen Doses for Critically Ill Patients May Be Falling Short

April 21, 2017

The researchers found that the maximum acetaminophen concentration was 33.6 µg/mL and the minimum concentration was 0.5µg/mL, after 1g doses every 6 hours.

Does Pregabalin Reduce Sciatica Intensity?

March 23, 2017

Two hundred nine patients were randomized to receive either pregabalin at a dose of 150mg per day, which was adjusted to a maximum of 600mg per day, or matching placebo for up to eight weeks.

Risk of Out-of-Hospital Cardiac Arrest Compared for NSAIDs

By March 15, 2017

A significantly increased risk of out-of-hospital cardiac arrest was seen with the use of diclofenac and ibuprofen.

Review: Efficacy of Intranasal Drug Delivery in Emergency Settings

By March 07, 2017

In this study, researchers reviewed the evidence on the use of IN administration for several medications commonly used in the emergency department.

Report Outlines Screening and Treating Pediatric Sexual Assault

February 28, 2017

Pediatricians should be comfortable with treating and screening for sexual assault, and they should know where to send their teenage patients for any additional help, according to a clinical report from the American Academy of Pediatrics (AAP) published online in Pediatrics.

Antidepressants Often Prescribed for Unapproved Uses

February 23, 2017

Trazodone for insomnia most common off-label use for antidepressants

Low Back Pain Treatment Guidelines Released

By February 14, 2017

The recommendations are intended for all clinicians treating adult patients with acute, suabcute, or chronic low back pain.

Is Diazepam Beneficial in Acute Low Back Pain?

By February 13, 2017

In the U.S., diazepam is prescribed in approximately 300,000 visits for low back pain annually, however the evidence regarding its efficacy is surprisingly lacking.

Certain Pain Meds May Have Significant Endocrinologic Effects

By February 10, 2017

Chronic pain patients being treated with certain opioid and non-opioid medications had significantly lower serum concentrations of free testosterone (fTe) and free estradiol (fE2), highlighting the potential endocrinologic side effects of these drugs. These were the findings of a new study published in the journal Drug Testing and Analysis.

Preconception-Initiated Aspirin May Prevent Pregnancy Loss in Certain Women

By February 07, 2017

According to a new study published in The Journal of Clinical Endocrinology & Metabolism, preconception-initiated low-dose aspirin may help prevent pregnancy loss in women with high levels of C-reactive protein (CRP) who have previously lost a pregnancy.

Efficacy Data for IV Ibuprofen Use in Children Published

By February 07, 2017

Cumberland announced the publication of new clinical data in BMC Pediatrics showing that treatment with Caldolor (ibuprofen) Injection led to significant fever reduction in hospitalized children.

Does NSAID Use Affect Bipolar Disorder Treatment Outcomes?

By February 01, 2017

The use of non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen, alone or together, does not appear to affect mood stabilizing treatment with lithium or quetiapine in patients with bipolar disorder. The full findings from the study are published in Depression and Anxiety.

Ofirmev Dosing Updated to Include Neonates, Infants

By February 01, 2017

The Food and Drug Administration (FDA) has approved labeling changes for Ofirmev (acetaminophen; Mallinckrodt) injection to include recommended dosing for treatment of fever in neonates and infants.

Study Reveals Most Common Drug Interactions Among Older Patients

By January 24, 2017

Findings from a cross-sectional study show that drug interactions are common among community-dwelling older adults and are related to the number of medications and hospitalization in the previous year.

Risk Factors Associated with NSAID Hypersensitivity Reaction ID'd

By January 23, 2017

Data from a retrospective cohort study found that about 1 in 5 non-steroidal anti-inflammatory drug (NSAID) adverse drug reactions is a hypersensitivity reaction.

NSAIDs and Aspirin Compared for Colorectal Cancer Prevention

By December 20, 2016

The efficacy of NSAIDs, aspirin, and supplements in preventing the recurrence of advanced neoplasia after polyp removal was evaluated in a new study.