An ongoing Phase 1b trial is currently testing CA-008 in patients undergoing bunionectomy, with results expected in the first quarter of 2018.
Compared to other commonly used opioids, buprenorphine offers a ceiling effect for respiratory depression and less abuse potential, less cognitive impairment, and less constipation.
The new and revised standards from The Joint Commission were published in July 2017 to address some of the issues associated with over-prescribing and lack of monitoring.
Results showed that after adjusting for maternal use of acetaminophen pre-pregnancy, familial risk and indications of acetaminophen use, the hazard ratio (HR) of ADHD with ≥29 days of acetaminophen use was 2.20 (95% CI; 1.50-3.24).
In bunionectomy and hernia repair HTX-011 (60mg and 300mg, respectively) was found to significantly reduced pain through 72 hours compared to placebo and bupivacaine (P=0.0003 and P=0.0106).
Participants were randomized to either hydromorphone 1mg (n=64) or prochlorperazine 10mg plus diphenhydramine 25mg (n=62).
Results found that all primary endpoints for non-inferiority of extended-release naltrexone group were met; retention in treatment (P=0.04), group proportion of total number of opioid-negative urine drug tests (P<0.001), days of heroin use (P<0.001) and days of other illicit opioids use (P<0.001).
The case involved a 30-year-old female with a history of anxiety and migraine who presented with complaints of malaise, right upper quadrant pain, worsening jaundice, dark colored urine, and itching; these symptoms had been going on for a few weeks.
Researchers conducted a randomized, double-blind study involving patients using chronic opioids who were scheduled to undergo colonoscopy.
The efficacy of Lyrica CR has not been established for the management of fibromyalgia or as adjunctive therapy for adult patients with partial onset seizures.
The Intellis platform records and monitors patient activity 24/7, which can be accessed by physicians to track and make treatment adjustments as needed.
In clinical trials, treatment with Durolane effectively relieved pain and restored function for up to six months in patients with knee osteoarthritis.
The PRECISION-ABPM study included 444 patients (408 with osteoarthritis; 36 RA) who had evidence of, or were at increased risk for, coronary artery disease.
The authors also noted that "as assessed by the marginal structural model, higher doses of pregabalin were estimated to result in a significantly greater change in mean pain score at each week."
For abortive medications, results showed that overall 18.9% of patients received all high quality abortive medication, 27% received some low quality abortive while 15.2% received opioids.
Gabapentinoids are increasingly being used for almost any type of pain. U.S. prescribing data support this, with gabapentin being the 10th most commonly prescribed medication in 2016.
The researchers found that off-treatment ARU was significantly reduced post-bariatric surgery versus pre-surgery levels (602±59 versus 531±78; P=0.035).
In general, the best available evidence pointed to self-management advice, exercise therapy and psychosocial interventions as effective strategies for managing musculoskeletal pain in primary care.
Virtual reality is much more than just a new form of entertainment, it is increasingly being used in a wide range of medical applications.
Their findings demonstrated that 3 or 4 out of 10 participants achieved this degree of pain relief with gabapentin, vs. 1 or 2 out of 10 for placebo.
The researchers administered detailed epidemiologic questionnaires to 2,419 patients age 18 to 74 years with incident invasive CRC, diagnosed from 1997 to 2008.
The study - billed as the world's largest randomized, controlled trial of acupuncture in the emergency department - included 528 patients.
Currently, there is a global Phase 3 program comprised of 6 studies involving approximately 7,000 patients with OA, CLBP or cancer pain with inadequate treatment of pain with approved therapies.
Compared with the 2 compounds used separately, the combination of EVOO and ibuprofen at its therapeutic dose showed superiority.