Nonnarcotic Analgesics

Novel Post-Surgical Pain Drug Granted Fast Track Designation

By December 07, 2017

An ongoing Phase 1b trial is currently testing CA-008 in patients undergoing bunionectomy, with results expected in the first quarter of 2018.

FDA to Review Novel Buprenorphine SL Spray for Acute Pain

By December 06, 2017

Compared to other commonly used opioids, buprenorphine offers a ceiling effect for respiratory depression and less abuse potential, less cognitive impairment, and less constipation.

ASHP: Revised Standards can Build Framework for Opioid Stewardship

December 06, 2017

The new and revised standards from The Joint Commission were published in July 2017 to address some of the issues associated with over-prescribing and lack of monitoring.

Minimally Invasive Treatment Found to Relieve Low Back Pain

November 30, 2017

Reductions in VAS, ODI, Roland Morris score for patients with acute, subacute neuroradicular pain

SCS Beneficial for Patients With Painful Diabetic Peripheral Neuropathy

November 20, 2017

After 5 years, more than half of patients with painful diabetic polyneuropathy had treatment success

Acetaminophen Use During Pregnancy Linked to Offspring ADHD

By October 30, 2017

Results showed that after adjusting for maternal use of acetaminophen pre-pregnancy, familial risk and indications of acetaminophen use, the hazard ratio (HR) of ADHD with ≥29 days of acetaminophen use was 2.20 (95% CI; 1.50-3.24).

Opioid Alternative Tx for Surgical Site Granted Fast Track Status

By October 26, 2017

In bunionectomy and hernia repair HTX-011 (60mg and 300mg, respectively) was found to significantly reduced pain through 72 hours compared to placebo and bupivacaine (P=0.0003 and P=0.0106).

Haloperidol Plus Conventional Tx Effective for Symptomatic Gastroparesis

By October 26, 2017

Haloperidol was superior to placebo in reducing nausea and pain.

Acetaminophen Evaluated for Postoperative Shivering

By October 25, 2017

Results showed that 22.2% and 73.7% experienced shivering postoperative in the acetaminophen and placebo groups, respectively.

Non-Opioid Tx Beats Hydromorphone for Migraine Pain Relief in the ED

By October 19, 2017

Participants were randomized to either hydromorphone 1mg (n=64) or prochlorperazine 10mg plus diphenhydramine 25mg (n=62).

Opioid Dependence Prevention Txs Compared in Head-to-Head Study

By October 18, 2017

Results found that all primary endpoints for non-inferiority of extended-release naltrexone group were met; retention in treatment (P=0.04), group proportion of total number of opioid-negative urine drug tests (P<0.001), days of heroin use (P<0.001) and days of other illicit opioids use (P<0.001).

Intrahepatic Cholestasis Following Regular Consumption of Herbal Tea

By October 17, 2017

The case involved a 30-year-old female with a history of anxiety and migraine who presented with complaints of malaise, right upper quadrant pain, worsening jaundice, dark colored urine, and itching; these symptoms had been going on for a few weeks.

Diphenhydramine Improves Procedural Sedation Quality for Chronic Opioid Users

October 17, 2017

Researchers conducted a randomized, double-blind study involving patients using chronic opioids who were scheduled to undergo colonoscopy.

FDA Approves Treatment for Two Neuropathic Pain Conditions

By October 12, 2017

The efficacy of Lyrica CR has not been established for the management of fibromyalgia or as adjunctive therapy for adult patients with partial onset seizures.

Gabapentin, Opioid Combo May Up the Risk of Opioid-Related Death

By October 03, 2017

Both gabapentin and opioids are commonly prescribed for the treatment of pain.

Intellis SC Stimulator Approved for Chronic Pain

By September 18, 2017

The Intellis platform records and monitors patient activity 24/7, which can be accessed by physicians to track and make treatment adjustments as needed.

Durolane Approved to Treat Knee Osteoarthritis Pain

By September 05, 2017

In clinical trials, treatment with Durolane effectively relieved pain and restored function for up to six months in patients with knee osteoarthritis.

Increases in BP, Hypertension Incidence Linked to Certain NSAIDs

By August 28, 2017

The PRECISION-ABPM study included 444 patients (408 with osteoarthritis; 36 RA) who had evidence of, or were at increased risk for, coronary artery disease.

Outcomes of Escalating Pregabalin Dose in Cases of Inadequate Response

By August 24, 2017

The authors also noted that "as assessed by the marginal structural model, higher doses of pregabalin were estimated to result in a significantly greater change in mean pain score at each week."

Opioids Greatly Overused as Migraine Treatment, Study Finds

By August 17, 2017

For abortive medications, results showed that overall 18.9% of patients received all high quality abortive medication, 27% received some low quality abortive while 15.2% received opioids.

Clinicians Increasingly Prescribing Gabapentinoids to Avoid Opioids

August 03, 2017

Gabapentinoids are increasingly being used for almost any type of pain. U.S. prescribing data support this, with gabapentin being the 10th most commonly prescribed medication in 2016.

'Smart' Undergarment Helps Reduce Stress on the Lower Back

By August 02, 2017

When wearing the clothing lower back activity was reduced by an average of 15 to 45%.

Aspirin-Induced Platelet Inhibition May Be More Potent Post-Bariatric Sx

July 20, 2017

The researchers found that off-treatment ARU was significantly reduced post-bariatric surgery versus pre-surgery levels (602±59 versus 531±78; P=0.035).

Treatments Compared for Managing Musculoskeletal Pain in Primary Care

By June 27, 2017

In general, the best available evidence pointed to self-management advice, exercise therapy and psychosocial interventions as effective strategies for managing musculoskeletal pain in primary care.

From Treatment to Training: 5 Uses of Virtual Reality in Healthcare

June 27, 2017

Virtual reality is much more than just a new form of entertainment, it is increasingly being used in a wide range of medical applications.

Analgesic Effects of Gabapentin Assessed in Chronic Neuropathic Pain

By June 26, 2017

Their findings demonstrated that 3 or 4 out of 10 participants achieved this degree of pain relief with gabapentin, vs. 1 or 2 out of 10 for placebo.

NSAID Use May Benefit Certain Colorectal Cancer Survivors

June 20, 2017

The researchers administered detailed epidemiologic questionnaires to 2,419 patients age 18 to 74 years with incident invasive CRC, diagnosed from 1997 to 2008.

Could Acupuncture Be an Effective Alternative to Pain Meds in the ER?

June 20, 2017

The study - billed as the world's largest randomized, controlled trial of acupuncture in the emergency department - included 528 patients.

First-in-Class Drug Candidate Fast Tracked for Chronic Pain

By June 14, 2017

Currently, there is a global Phase 3 program comprised of 6 studies involving approximately 7,000 patients with OA, CLBP or cancer pain with inadequate treatment of pain with approved therapies.

Can Olive Oil Enhance the Therapeutic Effect of Ibuprofen?

June 13, 2017

Compared with the 2 compounds used separately, the combination of EVOO and ibuprofen at its therapeutic dose showed superiority.