Generic Name and Formulations:
Nitroglycerin 0.3mg, 0.4mg, 0.6mg; sublingual tabs.
Acute relief of angina attack. Prophylaxis of angina pectoris.
Treatment: 1 tab sublingually or in buccal pouch at onset, may repeat in 5 minutes; max 3 tabs in 15 minutes. Prophylaxis: 5–10 minutes before activity.
Early MI. Severe anemia. Increased intracranial pressure. Concomitant sildenafil.
Acute MI, heart failure: monitor. Hypotensive or volume depleted. Hypertrophic cardiomyopathy. Avoid abrupt cessation. Discontinue if blurred vision or dry mouth occur. Elderly. Pregnancy (Cat.C). Nursing mothers.
See Contraindications. Hypotension potentiated by sildenafil, calcium channel blockers, alcohol, vasodilators, antihypertensives, β-blockers, phenothiazines, aspirin. May antagonize alteplase, heparin. Drugs that cause dry mouth (e.g., tricyclics, anticholinergics) may interfere with sublingual dissolution. Avoid ergotamine and related drugs. Tolerance to other forms of nitrates may blunt effects. May interfere with cholesterol tests.
Headache, vertigo, weakness, palpitation, orthostatic hypotension, tachycardia, syncope, flushing, rash, exfoliative dermatitis.
Tabs 0.4mg—4 x 25, 100; 0.3mg, 0.6mg—100