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NITROPRESS
Bleeding disorders
CHF and arrhythmias
Hypertension
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Drug Name:

NITROPRESS Rx

Generic Name and Formulations:
Sodium nitroprusside 25mg/mL; soln for IV infusion after dilution.

Company:
Hospira

Therapeutic Use:

Indications for NITROPRESS:

To produce controlled hypotension to reduce surgical bleeding.

Adults and Children:

Use infusion pump only. Monitor BP closely. Initially 0.3microgram/kg/min; may increase infusion rate every few minutes until desired effect; max 10microgram/kg/min and no more than 10 minutes. Titrate infusion rate (see literature).

Pharmacological Class:

Vasodilator.

Contraindications:

Compensatory hypertension due to aortic coarctation or arteriovenous shunting. Inadequate cerebral circulation or moribund patients requiring emergency surgery. Congenital (Lebers) optic atrophy. Tobacco amblyopia. Acute CHF associated with reduced peripheral vascular resistance.

Warnings/Precautions:

Use only when available equipment and personnel allow BP to be continuously monitored. Cyanide toxicity possible (esp. at infusion rates >2micrograms/kg/min); monitor acid-base disturbances and venous oxygen concentration. Elevated intracranial pressure. Correct pre-existing anemia and hypovolemia, esp. during anesthesia. Poor surigical risk. Hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Hypotensive effect potentiated by ganglionic blocking agents, negative inotropic agents, and inhaled anesthetics.

Adverse Reactions:

Excessive hypotension, cyanide toxicity, methemoglobinemia, abdominal pain, apprehension, diaphoresis, dizziness, headache, muscle twitch, nausea, palpitations, restlessness, rash, hypothyroidism, ileus, flushing, infusion site reactions.

How Supplied:

Single-dose vials (2mL)—100

Indications for NITROPRESS:

Acute CHF.

Adults and Children:

Use infusion pump only. Monitor BP closely. Initially 0.3microgram/kg/min; may increase infusion rate every few minutes until desired effect; max 10microgram/kg/min and no more than 10 minutes. Titrate infusion rate (see literature).

Pharmacological Class:

Vasodilator.

Contraindications:

Compensatory hypertension due to aortic coarctation or arteriovenous shunting. Inadequate cerebral circulation or moribund patients requiring emergency surgery. Congenital (Lebers) optic atrophy. Tobacco amblyopia. Acute CHF associated with reduced peripheral vascular resistance.

Warnings/Precautions:

Use only when available equipment and personnel allow BP to be continuously monitored. Cyanide toxicity possible (esp. at infusion rates >2micrograms/kg/min); monitor acid-base disturbances and venous oxygen concentration. Elevated intracranial pressure. Correct pre-existing anemia and hypovolemia, esp. during anesthesia. Poor surigical risk. Hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Hypotensive effect potentiated by ganglionic blocking agents, negative inotropic agents, and inhaled anesthetics.

Adverse Reactions:

Excessive hypotension, cyanide toxicity, methemoglobinemia, abdominal pain, apprehension, diaphoresis, dizziness, headache, muscle twitch, nausea, palpitations, restlessness, rash, hypothyroidism, ileus, flushing, infusion site reactions.

How Supplied:

Single-dose vials (2mL)—100

Indications for NITROPRESS:

Immediate reduction of blood pressure during hypertensive crises.

Adults and Children:

Use infusion pump only. Monitor BP closely. Initially 0.3microgram/kg/min; may increase infusion rate every few minutes until desired effect; max 10microgram/kg/min and no more than 10 minutes. Titrate infusion rate (see literature).

Pharmacological Class:

Vasodilator.

Contraindications:

Compensatory hypertension due to aortic coarctation or arteriovenous shunting. Inadequate cerebral circulation or moribund patients requiring emergency surgery. Congenital (Lebers) optic atrophy. Tobacco amblyopia. Acute CHF associated with reduced peripheral vascular resistance.

Warnings/Precautions:

Use only when available equipment and personnel allow BP to be continuously monitored. Cyanide toxicity possible (esp. at infusion rates >2micrograms/kg/min); monitor acid-base disturbances and venous oxygen concentration. Elevated intracranial pressure. Correct pre-existing anemia and hypovolemia, esp. during anesthesia. Poor surigical risk. Hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Hypotensive effect potentiated by ganglionic blocking agents, negative inotropic agents, and inhaled anesthetics.

Adverse Reactions:

Excessive hypotension, cyanide toxicity, methemoglobinemia, abdominal pain, apprehension, diaphoresis, dizziness, headache, muscle twitch, nausea, palpitations, restlessness, rash, hypothyroidism, ileus, flushing, infusion site reactions.

How Supplied:

Single-dose vials (2mL)—100

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