Which Drugs Up Dehydration, Heat-Related Illness Risk?

Starting ACE inhibitors + diuretics posed the highest risk of hospitalization
Starting ACE inhibitors + diuretics posed the highest risk of hospitalization

Starting ACE inhibitors in combination with diuretics posed the greatest risk of hospitalization for dehydration or heat-related illness, a study in the Journal of Clinical Pharmacy and Therapeutics found.

Previous studies have determined factors that increase the risk of heat-related illness but not much is known regarding the role of medicines. Researchers from Australia performed a retrospective analysis using prescription event symmetry analysis (PESA) of 6,700 veterans with incident hospital admission for dehydration or heat-related illness during January 1, 2001–June 30, 2013. The study's main outcome measure was first-ever hospital admission for dehydration or heat-related illness after initiating commonly used medicines. 

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Study authors found a significantly increased risk of hospital admission following initiation of anticoagulants, cardiovascular medicines, NSAIDs, antipsychotics, antidepressants, and anticholinergics. The risk of hospital admission for dehydration or heat-related illness ranged from 1.17 for SSRIs to 2.79 for ACE inhibitors + diuretic product. There was no significant association seen with hospital admission and initiation of anticonvulsants, anti-Parkinson's agents, hypnotics, anxiolytics or antihistamines. 

Overall, many medicines were associated with a higher risk of hospitalization for dehydration or heat-related illness. Both prescribers and patients should be aware of the potential for certain medicines to increase the risk of dehydration and heat-related illness, researchers concluded.

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