Vitamin B12 Therapy Linked to Acneform Eruptions

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Eruptions appeared from 1 week to 5 months after Tx initiation; remission after discontinuation
Eruptions appeared from 1 week to 5 months after Tx initiation; remission after discontinuation

HealthDay News — In a case report published online June 8 in the Journal of Cosmetic Dermatology, acneiform eruption associated with vitamin B12 therapy is described in 5 female patients ranging in age from 21 to 62 years.

Stefano Veraldi, MD, from the Università degli Studi di Milano in Italy, and colleagues present 5 cases of acneiform eruption caused by vitamin B12.

According to the authors, the cases of acneiform eruption occurred in 5 females aged 37, 32, 62, 29, and 21 years. The eruption was observed from 1 week to 5 months after initiation of intramuscular or oral vitamin B12 therapy. Papules and pustules located on the face characterized the clinical picture. Similar lesions were seen on the neck, shoulders, chest, and upper portion of the back in 3 patients. There were no comedones or cysts. Serum vitamin B12 levels were very high in 2 patients. In 1 patient, histologic examination revealed an eosinophilic folliculitis. At 3 to 6 weeks after vitamin B12 discontinuation, spontaneous and complete remission was observed. 

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"A careful pharmacologic history is therefore necessary in all patients with acneiform eruptions," the authors write.

Abstract
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