Underlying Mechanisms ID'd in Curcumin Resensitization of CA Cells

Compound helps turn off pathways linked to chemoresistance in pancreatic ductal adenocarcinoma
Compound helps turn off pathways linked to chemoresistance in pancreatic ductal adenocarcinoma

HealthDay News — Curcumin can resensitize chemoresistant pancreatic ductal adenocarcinoma (PDAC) cells through inhibition of the polycomb repressive complex 2 (PRC2)-PVT1-c-Myc axis, according to a study published online July 17 in Carcinogenesis.

Noting that curcumin can overcome de-novo chemoresistance and resensitize tumors to chemotherapeutic agents, Kazuhiro Yoshida, MD, from the Baylor University Medical Center in Dallas, and colleagues examined the underlying mechanisms for curcumin-mediated chemosensitization. 

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The researchers reported the resensitization of chemoresistant PDAC cells by curcumin through inhibition of the PRC2-PVT1-c-Myc axis. Curcumin sensitized chemoresistant cancer cells inhibited expression of the PRC2 subunit enhancer of zeste homolog-2 and its related long non-coding RNA PVT1 using gemcitabine-resistant PDAC cell lines. Curcumin also prevented spheroid formation and down-regulated several genes driving self-renewal. In vitro findings were confirmed in a xenograft mouse model, with inhibition of gemcitabine-resistant tumor growth by curcumin.

"Overall, this study establishes clinical relevance for combining curcumin with chemotherapy to overcome chemoresistance in PDAC," the authors write.

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