Intervention Demonstrates Significant T2D Remission in Primary Care

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Implementation of intensive weight management program linked to remission in 46% of patients
Implementation of intensive weight management program linked to remission in 46% of patients

HealthDay News — Intensive weight management implemented in primary care practices can result in remission of type 2 diabetes for almost half of patients, according to a study published online December 5 in The Lancet.

Michael E.J. Lean, MD, from the University of Glasgow in the United Kingdom, and colleagues randomized 49 primary care practices in a 1:1 ratio to provide a weight management program (intervention) or best-practice care by guidelines (control). A total of 306 individuals aged 20 to 65 years who had been diagnosed with type 2 diabetes in the past 6 years, had a body mass index of 27 to 45kg/m², and were not receiving insulin were recruited. 

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The researchers recorded weight loss of 15kg or more in 24 participants in the intervention group and none in the control group at 12 months (P<0.0001). Diabetes remission was achieved by 46 and 4% of participants in the intervention and control groups, respectively (odds ratio, 19.7). In the whole study population, remission varied with weight loss; remission was achieved by none of those who gained weight, 7, 34, 57, and 86% of participants who maintained 0 to 5kg weight loss, had 5 to 10kg weight loss, had 10 to 15kg weight loss, and who lost 15kg or more, respectively.

"Remission of type 2 diabetes is a practical target for primary care," the authors write.

Several disclosed financial ties to the pharmaceutical and weight loss industries.

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