Topiramate May Be Effective for Alcohol Use Disorder, PTSD Symptoms

the MPR take:

Topiramate has been used for the treatment of seizures and migraines but a new study published in the journal Alcoholism Clinical & Experimental Research examines whether the drug can help reduce alcohol use and posttraumatic stress disorder (PTSD) symptoms.  The 12-week placebo-controlled trial included 30 veterans with PTSD and alcohol use disorder (AUD), with the primary outcome measure being frequency of drinking and secondary outcomes being alcohol use (by other measures) and PTSD symptom severity.  In this study, doses of up to 300mg/day of topiramate were used.  Results showed that topiramate significantly reduced the frequency and amount of alcohol used as well as alcohol cravings compared with placebo. Topiramate treatment was also associated with reduced PTSD symptom severity and hyperarousal symptoms.  Researchers conclude that the drug may be effective for treating AUD and PTSD symptom severity however it should be noted that treatment was associated with transient cognitive impairment. 

Topiramate May Be Effective for Alcohol Use Disorder, PTSD Symptoms
Topiramate May Be Effective for Alcohol Use Disorder, PTSD Symptoms
The course of posttraumatic stress disorder (PTSD) is frequently and severely complicated by co-occurring alcohol use disorder (AUD), yet there are few reports of pharmacologic treatments for these comorbid conditions.

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