Time to Reperfusion Vital to Improved Acute Stroke Outcomes

Among patients with acute stroke treated with stent retrievers, fast reperfusion tied to better outcomes
Among patients with acute stroke treated with stent retrievers, fast reperfusion tied to better outcomes

HealthDay News — Among patients with acute stroke treated with stent retrievers, fast reperfusion leads to improved functional outcome, according to a study published in the June issue of Radiology.

Mayank Goyal, MD, from the University of Calgary in Canada, and colleagues examined the correlation between functional independence and time to reperfusion in the Solitaire with the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT PRIME) trial. Outcomes were compared in patients treated with intravenous tissue plasminogen activator alone or in combination with the Solitaire device.

The researchers found that a symptom onset to reperfusion time of 150 minutes led to 91% estimated probability of functional independence in the stent retriever arm of the study, which decreased by 10% over the next hour and by 20% with every subsequent hour of delay. From arrival at the emergency department, the time to arterial access was 90 minutes and time to reperfusion was 129 minutes. Compared with patients who presented directly to the endovascular-capable center, patients who initially arrived at a referring facility had longer symptom onset to groin puncture times (275 versus 179.5 minutes; P<0.001).

"Fast reperfusion leads to improved functional outcome among patients with acute stroke treated with stent retrievers," the authors write.

Several authors disclosed financial ties to pharmaceutical and medical device companies, including Covidien, which funded the SWIFT PRIME trial and manufactures the Solitaire device.

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