Tadalafil Ineffective for ED Post-Radiotherapy in Prostate Cancer
the MPR take:
New research in JAMA found that daily use of tadalafil did not result in improved erectile function after radiotherapy for prostate cancer, compared with placebo. The stratified, placebo-controlled, double-blind, parallel-group study of 221 patients at 76 community-based and tertiary medical sites in the US and Canada assigned participants either 5mg of tadalafil daily or placebo for 24 weeks beginning with external radiotherapy or brachytherapy. Patients taking tadalafil did not report a significant overall improvement in sexual function or satisfaction; their partners also found no significant impact on sexual satisfaction and marital adjustment. The use of tadalafil daily to prevent erectile dysfunction in these patients is not supported by these findings, the authors state.
Importance: Tadalafil is used to treat erectile dysfunction after prostate cancer treatment, but its role as a preventive agent is undefined. Interventions: One hundred twenty-one participants were assigned 5 mg of tadalafil daily and 121 were assigned placebo for 24 weeks starting with external ...
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