Researchers Link Biomarker to Insulin Sensitivity, Independent of CRP

N-acetylglucosamine/galactosamine independently associated with insulin sensitivity index
N-acetylglucosamine/galactosamine independently associated with insulin sensitivity index

HealthDay News — N-acetylglucosamine/galactosamine (GlycA) is associated with insulin sensitivity, independent of C-reactive protein (CRP), according to a study published online in Diabetes Care.

Carlos Lorenzo, MD, from the University of Texas Health Science Center in San Antonio, and colleagues conducted cross-sectional analyses involving 1,225 participants with and without type 2 diabetes in the Insulin Resistance Atherosclerosis Study. The authors examined the relation of GlycA, sialic acid (GlycB), and CRP to direct measures of insulin sensitivity (insulin sensitivity index [SI]) and insulin secretion (acute insulin response [AIR]). 

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The researchers observed a strong correlation for GlycA and GlycB with CRP (both P<0.001). In a linear regression model with both GlycA and CRP as independent variables, there was an independent association for GlycA and CRP with SI, even after adjustment for demographics, smoking, physical activity, plasma glucose, and body mass index. There was no independent correlation for CRP or GlycA with AIR.

"GlycA may complement CRP in evaluating the relationship between inflammation, glucose tolerance, and insulin resistance," the authors write.

One author is employed by Eli Lilly and Company.

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