Predictive Factors in Laryngeal SCC Recurrence

WHO performance status >0, neck metastasis, nonsurgical treatment predict recurrence
WHO performance status >0, neck metastasis, nonsurgical treatment predict recurrence

HealthDay News — For patients with laryngeal squamous cell carcinoma (SCC), factors predictive of recurrence include neck metastasis at presentation and nonsurgical treatment, according to a study published online November 30 in Head & Neck.

Aaro Haapaniemi, MD, from Helsinki University Hospital in Finland, and colleagues analyzed a nationwide laryngeal SCC cohort from Finnish university hospitals during 2001 to 2005. Data were included for 316 patients with initial successful therapy. 

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The researchers found that 22% of patients had laryngeal SCC recurrence. The median time to recurrence was nine months, and 90% within 36 months following treatment. Independent prognostic factors for recurrence included the World Health Organization performance status >0, neck metastasis at presentation, and nonsurgical treatment. Five-year overall survival was 53% for patients with local recurrence and 5% for patients with regional/distant recurrences. For glottic and nonglottic laryngeal SCC recurrence, overall survival was 45 and 0%, respectively.

"The type of treatment affected the risk of recurrence in this retrospective series. Local recurrences carried a chance for successful salvage treatment," the authors write. "Routine follow-up beyond 36 months remains controversial."

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