Exendin Assessed for Post-Bariatric Complications
HealthDay News — Subcutaneous exendin (SC Ex-9) appears to be safe and effective in treating post-bariatric hypoglycemia (PBH), according to a study published online August 4 in Diabetes, Obesity and Metabolism.
Colleen M. Craig, MD, from the Stanford University School of Medicine in California, and colleagues conducted the first in-human subcutaneous administration of Ex-9 in nine female patients with PBH following Roux-en-Y gastric bypass. First, a single participant underwent equimolar low-dose IV versus subcutaneous Ex-9 administration. Then, eight participants were administered single ascending doses of SC Ex-9 during oral glucose tolerance testing.
The researchers observed an exposure-response relationship, but all doses effectively prevented hyperinsulinemic hypoglycemia and improved associated symptoms. The postprandial glucose nadir was increased by 66%, peak insulin was reduced by 57%, and neuroglycopenic symptoms were reduced by 80%, on average. No treatment-related adverse events were reported.
"SC Ex-9 appears to represent a safe, effective, and targeted therapeutic approach for treatment of PBH," the authors write. "Further investigation involving multiple doses with chronic dosing is warranted."
Several authors disclosed financial ties to the pharmaceutical industry.