New Possible Target Against Gastric Injury Studied

New Possible Target Against Gastric Injury Studied
New Possible Target Against Gastric Injury Studied

Understanding the stomach's immune response to Helicobacter pylori infection may help develop new treatments against gastric damage, according to a recent report published in Cellular and Molecular Gastroenterology and Hepatology.

Researchers evaluated interleukin (IL)-33 levels in mouse and human biopsy specimens infected with H. pylori and in mice after dosing with aspirin. IL-33 is an important signal expressed in gastric mucosa that triggers necessary changes for handling the injuries caused by infection. Mice were given one or seven daily doses of recombinant IL-33 (1mcg/dose) and the stomach and spleen responses were quantified morphologically.

RELATED: H. pylori Eradication Treatment Regimens

They found that during an acute response to an infection in mice, interleukin (IL)-33 levels were elevated four-fold but reduced two-fold in chronic infection. Human biopsy specimens with H. pylori presence also showed a reduced IL-33 expression.

Authors concluded that the decreased IL-33 expression after prolonged H. pylori infection may enable the T helper 1-biased immune response seen during H. pylori infection and the precancerous progression. Further studies are needed to determine the impact of IL-33 in different stages of gastric cancer.

For more information visit Gastro.org.

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