New Formulation of Antibiotic Cubicin Available

The new formulation can be stored at room temperature and be diluted with sterile or bacteriostatic water
The new formulation can be stored at room temperature and be diluted with sterile or bacteriostatic water

Merck announced the launch of Cubicin RF (daptomycin for injection), a new formulation of Cubicin

Both Cubicin and Cubicin RF are antibacterial injectables indicated for the treatment of complicated skin and skin structure infections caused by susceptible isolates, and for Staphylococcus aureus bloodstream infections, including those with right-sided infective endocarditis. 

The major differences between Cubicin and Cubicin RF have to do with reconstitution and storage. Cubicin RF may be stored at room temperature and not at refrigerated temperatures. Cubicin requires 0.9% sodium chloride as a diluent for reconstitution whereas Cubicin RF uses sterile or bacteriostatic water. To prepare for administration, Cubicin RF should be rotated or swirled for a few minutes to obtain a completely reconstituted solution. 

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Once reconstituted with sterile water for injection, Cubicin RF vials have an in-use shelf life at room temperature for 1 day and 3 days if refrigerated. If reconstituted with bacteriostatic water for injection, Cubicin RF vials have an in-use shelf life at room temperature for 2 days and 3 days if refrigerated. Cubicin RF as an intravenous (IV) bag has an in-use shelf life of 19 hours (room temperature) and 3 days (refrigerated) if reconstituted with sterile water for injection and 2 days (room temperature) and 5 days (refrigerated) if reconstituted with bacteriostatic water. Cubicin RF syringes have an in-use shelf life of 1 day (room temperature) and 3 days (refrigerated) if reconstituted with sterile water for injection, or 2 days (room temperature) and 5 days (refrigerated) if reconstituted with bacteriostatic water. 

Cubicin vials and IV bags both have in-use shelf lives of 12 hours at room temperature or 48 hours if refrigerated. 

Cubicin RF and Cubicin are available as a 500mg per vial strength lyophilized powder in single-dose 10mL vials. 

For more information call (877) 888-4231 or visit Cubicin.com

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