New Finding Could Explain Gender Gap in MS
the MPR take:
The blood vessel receptor protein S1PR2 could provide an explanation as to why women are four times more likely to be diagnosed with multiple sclerosis (MS). Researchers at Washington University School of Medicine examined the blood vessels and brains of healthy mice, mice with MS, and mice without the gene for S1PR2 along with brain tissue samples of 20 people with MS after they had died. Higher levels of S1PR2 were found in both female mice and women in the areas of the brain typically damaged by MS and was positively correlated to the severity of the disease, compared to male mice and men. It is theorized that S1PR2 may work to make the blood-brain barrier more permeable, thus allowing the MS-causing cells into the central nervous system.
A key difference in the brains of male and female MS patients may explain why more women than men get the disease, a study suggests. Scientists at Washington University School of Medicine in the US found higher levels of protein S1PR2 in tests on the brains of female mice and dead women with MS ...
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