Molecule Discovery Could Lead to New Parkinson's Drug

Molecule Discovery Could Lead to New Parkinson's Drug
Molecule Discovery Could Lead to New Parkinson's Drug

Research published in The Journal of Biological Chemistry suggests that a newly designed molecule, if developed into a drug, could slow the progression of Parkinson's disease.

Because deposition of α-synuclein into Lewy bodies is considered a causative agent in the pathogenesis of Parkinson's, researchers from the University of Bath developed a 10 amino-acid peptide molecule via screening a library of peptides based on the region of α-synuclein that is mutated in patients with early onset Parkinson's. The molecule stopped α-synuclein clumping in living cells in this study, which is the first to assess this part of the α-synuclein protein as a potential drug target.

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Next steps for the research team include testing the peptide in mammalian neurone cells; if this is successful, the authors hope to initiate the development of a drug utilizing this molecule for use in humans to slow or stop the progression of Parkinson's.

For more information visit Bath.ac.uk.