MicroRNAs May Help Predict Osteoarthritis

Recent findings identify a correlation between the presence of biomarkers in the blood (micro RNAs [miRNAs]) and the development of severe osteoarthritis of the knee or hip joint, as presented at the European League Against Rheumatism Annual Congress (EULAR 2014).

The study examined existing serum samples of patients with osteoarthritis, through which they identified 3 potential miRNAs. A total of 816 patients were followed for >15 years and were measured for the presence of the 374 miRNAs and the occurrence of osteoarthritis. Arthroplasty was a definitive outcome of severe osteoarthritis in the knee or hip. Of the total patients, 67 had 1 or more total joint replacements for severe knee or hip osteoarthritis.

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Analysis results showed a correlation between severe knee or hip osteoarthritis and 3 miRNAs: let-7e, miR-454, and miR-885-5p. Researchers suggest that these miRNAs may be used as biomarkers to predict severe osteoarthritis in patients.

For more information visit EULAR.org.

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