Liraglutide vs. Lixisenatide as Add-On to Metformin in T2DM

Add-on liraglutide more effective than lixisenatide for improving glycemic control
Add-on liraglutide more effective than lixisenatide for improving glycemic control

(HealthDay News) — For patients with type 2 diabetes taking metformin, add-on liraglutide is more effective than lixisenatide for improving glycemic control, according to a study published online June 16 in Diabetes Care.

Michael Nauck, M.D., from the Ruhr-University Bochum in Germany, and colleagues conducted a 26-week randomized trial involving 404 patients with type 2 diabetes not achieving adequate glycemic control on metformin alone. Participants were randomized in a 1:1 ratio to liraglutide (administered once daily at any time of the day) or lixisenatide (administered once daily within one hour prior to morning or evening meal).

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The researchers found that hemoglobin A1c (HbA1c) was reduced more with liraglutide than lixisenatide at week 26 (estimated treatment difference −0.62 percent; P < 0.0001), with more patients reaching HbA1c <7 percent and ≤6.5 percent (both P < 0.0001). Liraglutide correlated with a greater reduction in fasting plasma glucose (estimated treatment difference, −1.15 mmol/L; P < 0.0001). There was a greater reduction in mean nine-point self-measured plasma glucose with liraglutide (P < 0.0001). Similar body weight decreases were seen for both drugs (−4.3 kg for liraglutide and −3.7 kg for lixisenatide; P = 0.23).

"At the dose levels studied, liraglutide was more effective than lixisenatide as add-on to metformin in improving glycemic control," the authors write.

Several authors disclosed financial ties to biopharmaceutical companies, including Novo Nordisk, which manufactures liraglutide and funded the study.

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