Ketamine as Therapy for Resistant Major Depression

the MPR take:

The first study to show benefits of using an intranasal formulation of ketamine for treatment-resistant major depressive disorder has been published in the journal Biological Psychiatry.The double-blind, crossover study, randomized 20 patients with major depressive disorder to receive ketamine (50mg dose) or saline. Depressive symptoms improved significantly in patients given ketamine versus placebo. Out of 18 patients, 8 subjects met response criteria to ketamine within 24 hours of the dose, compared to one in the saline group. The intranasal delivery method is non-invasive, offers quick delivery of the medication, and could improve compliance. 

Ketamine as Therapy for Resistant Major Depression
Ketamine as Therapy for Resistant Major Depression
Results from a newly published study indicate that intranasal ketamine spray can produce a rapid and sustained antidepressant effect within 24 hours, and was well tolerated in a small group of patients with treatment-resistant major depressive disorder. In the study, ketamine was found to be ...

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