How Does Vitamin D Level Affect Diabetes Complications?

257 patients who experienced diabetic microvascular complication participated in the study
257 patients who experienced diabetic microvascular complication participated in the study

A serum vitamin D level <10ng/mL was independently linked to an increased incidence of diabetic peripheral neuropathy in males, and an increased incidence of diabetic nephropathy in females with type 2 diabetes mellitus, according to a study published in Nutrition Research

Researchers from Soonchunhyang University College of Medicine, South Korea, studied the association between serum 25-hydroxyvitamin D (25[OH]D) and microvascular complications in type 2 diabetes mellitus. The team proposed that lower 25(OH)D would be linked to higher microvascular complications in type 2 diabetes mellitus. 

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They enrolled a total of 257 patients who experienced diabetic microvascular complication (eg, peripheral neuropathy, neuropathy, retinopathy). They were categorized based on vitamin D status: vitamin D sufficient (≥20ng/mL; n=41), vitamin D insufficient (10-<20ng/mL; n=132), and vitamin D deficient (<10ng/mL; n=84). 

The prevalence of diabetic peripheral neuropathy was significantly higher in males who were vitamin D deficient (38%) than those who were insufficient (11.7%) or sufficient (10%). When men in the vitamin D sufficient group were used as reference, the vitamin D deficient group had an increased risk of diabetic peripheral neuropathy after adjusting for confounding variables (OR, 7.79; 95% CI, 1.52–40.05). 

The prevalence of diabetic nephropathy was significantly higher in women who were vitamin D deficient (40%) than in those who were insufficient (20.6%) or sufficient (0%). When women in the vitamin D sufficient group were used as reference, the vitamin D deficient group had an increased risk of diabetic nephropathy after adjusting for confounding variables (OR 4.27; 95% CI, 1.58–11.56). 

For more information visit nrjournal.com.

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