How Does ART Affect HCV Replication in HIV/HCV Co-Infected Patients?

the MPR take:

What are the affects of HIV combination antiretroviral therapy (cART) on hepatitis C virus (HCV) replication in patients co-infected with HIV/HCV? A study in the journal Science Translational Medicine reports that while initially the use of cART in co-infected patients led to a transient increase in HCV replication and liver injury, over time HCV viral loads decreased to levels usually seen in patients with HCV monoinfection. Co-infection with HIV/HCV increases HCV replication which may lead to rapid liver disease progression.  Based on these findings, researchers support early use of cART in co-infected patients.

[Research Articles] Modulation of HCV replication after combination antiretroviral therapy in HCV/HI
[Research Articles] Modulation of HCV replication after combination antiretroviral therapy in HCV/HI
The hepatitis C virus (HCV) is an important contributor to morbidity and mortality in patients co-infected with HIV. Co-infection results in increased HCV replication and more rapid rates of liver disease progression. The effect of HIV combination antiretroviral therapy (cART) on HCV replication has not been studied in depth.

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