How Does ART Affect HCV Replication in HIV/HCV Co-Infected Patients?
the MPR take:
What are the affects of HIV combination antiretroviral therapy (cART) on hepatitis C virus (HCV) replication in patients co-infected with HIV/HCV? A study in the journal Science Translational Medicine reports that while initially the use of cART in co-infected patients led to a transient increase in HCV replication and liver injury, over time HCV viral loads decreased to levels usually seen in patients with HCV monoinfection. Co-infection with HIV/HCV increases HCV replication which may lead to rapid liver disease progression. Based on these findings, researchers support early use of cART in co-infected patients.
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