Hep B Comorbidities Linked to Hepatic, Cardio Events and Death

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A total of 1,466 CHB patients were assessed for LSM with transient elastography and detailed metabolic profiling
A total of 1,466 CHB patients were assessed for LSM with transient elastography and detailed metabolic profiling

HealthDay News — For patients with chronic hepatitis B (CHB), liver stiffness measurement (LSM) is associated with hepatic events and death, while metabolic syndrome increases the risk of cardiovascular events, according to a study published online October 1 in Hepatology.

Jenny Yeuk-Ki Cheng, from the Chinese University of Hong Kong, and colleagues recruited 1,466 CHB patients for LSM with transient elastography and detailed metabolic profiling. Patients were followed for any clinical event. 

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The researchers found that 93 and 44 patients developed hepatic and cardiovascular events, respectively, at a mean follow-up of 88 ± 20 months; 70 patients died. The cumulative probability of hepatic events was higher for patients with baseline LSM >8.0 kPa versus ≤8.0 kPa at eight years (12.3 versus 3.1%; P<0.001). The cumulative probability of cardiovascular events was higher for patients with metabolic syndrome (8.0 versus 2.1%; P<0.001). High LSM had no impact on cardiovascular events, and metabolic syndrome had no effect on hepatic events. LSM >8.0 kPa was an independent risk factor for death (adjusted hazard ratio, 1.9; 95% confidence interval, 1.1 to 3.2); metabolic syndrome was not (adjusted hazard ratio, 1.3; 95% confidence interval, 0.8 to 2.4).

"Metabolic syndrome increased the risk of cardiovascular events but not hepatic events and death; LSM was the important risk factor of hepatic events and death in CHB patients," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

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