Research ID's Gene Mutations Which May Predict Lethal Prostate Cancer

After adjustment for covariates, mutation carrier remained independent predictor of lethal PCa
After adjustment for covariates, mutation carrier remained independent predictor of lethal PCa

HealthDay News — The rate of germline BRCA1/2 and ATM mutations is significantly higher among patients with lethal prostate cancer (PCa) and is an independent predictor of lethal PCa, according to a study published online December 15 in European Urology.

Rong Na, from Fudan University in Shanghai, and colleagues directly assessed whether germline mutations in BRCA1/2 and ATM distinguish lethal from indolent PCa. Data were included from a retrospective study of 313 patients who died of PCa and 486 with low-risk localized PCa of European, African, and Chinese descent. Germline DNA from all patients was sequenced for these genes. 

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The researchers found that lethal PCa patients had a significantly higher combined BRCA1/2 and ATM mutation rate compared with localized PCa patients (6.07 versus 1.44%; P=0.0007). Among lethal PCa patients the rate also differed significantly as a function of age at death (P=0.046) and time to death after diagnosis (P=0.0006). After adjustment for race and age, prostate-specific antigen, and Gleason score at the time of diagnosis, being a mutation carrier remained an independent predictor of lethal PCa (hazard ratio, 2.13; P=0.004).

"Mutation status of BRCA1/2 and ATM distinguishes risk for lethal and indolent PCa and is associated with earlier age at death and shorter survival time," the authors write.

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