Inositol Investigated for Possible Gestational Diabetes Prevention

Findings among women with a family history of diabetes
Findings among women with a family history of diabetes

HealthDay News — Inositol supplementation in early pregnancy does not prevent gestational diabetes mellitus (GDM) in women with a family history of diabetes, according to a study published online March 21 in Diabetes Care.

Maria Farren, MB, BCh, from the Coombe Women & Infants University Hospital in Dublin, and colleagues conducted a randomized controlled trial in which 240 women with a family history of diabetes were enrolled at their first prenatal visit to receive either a combination of 1,100mg myo-inositol, 27.6g D-Chiro inositol, and 400mcg folic acid (intervention group) or 400mcg folic acid only (control group). An oral glucose tolerance test was administered between 24 and 28 weeks of gestation. 

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The researchers observed no difference in incidence of GDM between the groups. There were 28 cases of GDM in the intervention group and 22 in the control group (P=0.34). Both groups had a mean fasting plasma glucose of 81mg/dL at the glucose tolerance test.

"Further studies are required to examine whether inositol supplements at varying doses may prevent GDM," the authors write.

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