Fusilev Ready-to-Use Formulation Available

Spectrum Pharmaceuticals announced that the FDA has approved a “Ready-to-Use” (RTU) formulation of Fusilev (levoleucovorin) for injection. The RTU formulation requires no reconstitution, and is of a higher strength than the currently available lyophilized formulation. Fusilev, the pharmacologically active isomer of leucovorin, is available in vials as freeze-dried powder and single-use vials containing 17.5mL and 25mL sterile solution.

Fusilev rescue is indicated after high-dose methotrexate therapy in osteosarcoma. Fusilev is also indicated to diminish the toxicity and counteract the effects of impaired methotrexate elimination and of inadvertent overdosage of folic acid antagonists.

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