For HIV-Infected Patients, Depression May Up Risk of MI

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HIV-infected adults with major depressive disorder have ~30 percent increased risk for AMI
HIV-infected adults with major depressive disorder have ~30 percent increased risk for AMI

HealthDay News — For HIV-infected adults, major depressive disorder (MDD) is associated with an increased risk of acute myocardial infarction (AMI), according to a study published online August 24 in JAMA Cardiology.

Tasneem Khambaty, PhD, from the University of Miami in Coral Gables, and colleagues examined whether depressive disorders are associated with incident AMI in a cohort of 26,144 HIV-infected veterans with cardiovascular disease (CVD). At baseline, 19% of veterans had MDD and 9% had dysthymic disorder.

The researchers found that there were 490 AMI events (1.9%) during 5.8 years of follow-up. After adjustment for demographics, CVD risk factors, and HIV-specific factors, baseline MDD correlated with incident AMI (hazard ratios, 1.31 [95% confidence interval (CI), 1.05 to 1.62], 1.29 [95% CI, 1.04 to 1.60], and 1.30 [95 percent CI, 1.05 to 1.62], respectively). The associations were attenuated after further adjustment for hepatitis C, renal disease, substance abuse, and hemoglobin level (hazard ratio, 1.25; 95% CI, 1.00 to 1.56) and antidepressant use (hazard ratio, 1.12; 95% CI, 0.87 to 1.42). There was no correlation for baseline dysthymic disorder with incident AMI.

"Our findings raise the possibility that MDD may be independently associated with incident atherosclerotic CVD in the HIV-infected population," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

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