Fluticasone Improves Histologic Eosinophilia in Esophagitis

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Fluticasone Improves Histologic Eosinophilia in Esophagitis
Fluticasone Improves Histologic Eosinophilia in Esophagitis

(HealthDay News) — Swallowing aerosolized fluticasone improves histologic eosinophilia but does not improve dysphagia symptoms in adults with eosinophilic esophagitis (EoE), according to a study published online in the July issue of Clinical Gastroenterology and Hepatology.

To determine whether aerosolized fluticasone therapy improved symptomatic dysphagia and histologic eosinophilia, Jeffrey A. Alexander, MD, of the Mayo Clinic College of Medicine in Rochester, MN, and colleagues conducted a randomized, double-blind, placebo-controlled trial involving adults (mean age, 37.5 years) with a new diagnosis of EoE. For six weeks, patients either swallowed 880µg of aerosolized fluticasone (21 participants) or used a placebo inhaler twice daily (15 participants).

The researchers found that 62% of fluticasone-treated patients showed a complete histologic response, defined as a >90% reduction in mean eosinophil count, compared with none in the placebo group, in intention-to-treat analysis. In per-protocol analysis, 68% vs. 0% had a histologic response. Eighty-one vs. 8% of fluticasone- vs. placebo-treated patients exhibited reduced eosinophil-derived neurotoxin staining. Dysphagia was reduced in 57% and 33% of patients treated with fluticasone and placebo, respectively (P=0.22), in intention-to-treat analysis, and in 63% and 47%, respectively (P=0.49), in per-protocol analysis. Esophageal candidiasis developed in 26% of fluticasone-treated patients and no patients in the placebo group.

"In summary, this double-blind, placebo-controlled six-week trial of aerosolized fluticasone in the treatment of EoE found the treatment efficacious at decreasing esophageal eosinophilia and eosinophil activity," the authors write. "This histologic response, however, was not accompanied by a relief of symptomatic dysphagia."

One author disclosed financial ties to Meritage Pharmacia.

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