Cutaneous Procedures During Isotretinoin Rx May Be OK

Mechanical dermabrasion and fully ablative laser not recommended in setting of systemic treatment
Mechanical dermabrasion and fully ablative laser not recommended in setting of systemic treatment

HealthDay News — There is insufficient evidence to support delaying several cutaneous surgical procedures in the setting of systemic isotretinoin therapy, although mechanical dermabrasion and fully ablative laser are not recommended, according to a review published online June 28 in JAMA Dermatology.

Leah K. Spring, DO, from the Naval Hospital Camp Lejeune in North Carolina, and colleagues conducted a systematic literature review to develop evidence-based recommendations relating to the safety of procedural interventions performed concurrently with or following cessation of systemic isotretinoin therapy. Data were included from 32 relevant publications, which reported 1,485 procedures. 

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The researchers found that for patients currently receiving or having recently completed isotretinoin therapy, there was insufficient evidence to support delaying manual dermabrasion, superficial chemical peels, cutaneous surgery, laser hair removal, and fractional ablative and nonablative laser procedures. In the setting of systemic isotretinoin treatment, mechanical dermabrasion and fully ablative laser are not recommended.

"For some patients and some conditions, an informed decision may lead to earlier and potentially more effective interventions," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

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