C-Reative Protein Levels and Spontaneous Urticaria: Is There a Link?

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Elevated levels appear clinically relevant in patients with condition
Elevated levels appear clinically relevant in patients with condition

HealthDay News — C-reactive protein (CRP) levels are frequently elevated in patients with chronic spontaneous urticaria (CSU), and these elevations are relevant and potentially useful in management of the condition, according to a study published online November 12 in Allergy.

Pavel Kolkhir, MD, PhD, from Charité - Universitätsmedizin Berlin, and colleagues retrospectively analyzed data from 1,253 CSU patients from 2 centers to determine the prevalence of elevated levels of CRP. Serum CRP was measured using the nephelometric method.  

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The researchers found that one-third of patients exhibiting CSU had elevated levels of CRP. Factors associated with higher levels of CRP included autologous serum skin test positivity (P= 0.009) and arterial hypertension (P=0.005). CRP correlated with urticaria activity (P<0.001) and quality-of-life impairment (P=0.026), as well as inflammatory and coagulation markers (P<0.001). Compared to patients who did responded to antihistamines, CRP levels were significantly higher in non-responders (P<0.001).

"The assessment of CRP levels may help to optimize the management of patients with CSU," the authors write.

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