Sleep Duration, Quality Tied to Chronic Kidney Disease Progression

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Shorter sleep duration, greater sleep fragmentation linked to greater decline in eGFR
Shorter sleep duration, greater sleep fragmentation linked to greater decline in eGFR

(HealthDay News) — Shorter sleep duration and poor sleep quality are associated with progression of chronic kidney disease (CKD), according to a study published online Sept. 14 in the Journal of the American Society of Nephrology.

Ana C. Ricardo, M.D., from the University of Illinois at Chicago, and colleagues examined the correlation of habitual sleep duration and quality with progression of CKD in 431 participants in the Chronic Renal Insufficiency Cohort.

Participants slept an average of 6.5 hours/night, with mean sleep fragmentation of 21 percent. The researchers identified 70 end-stage renal disease (ESRD) events and 48 deaths over a median follow-up of five years. Greater sleep fragmentation was associated with increased ESRD risk (hazard ratio, 1.04 per 1 percent increase in fragmentation), in adjusted analyses. Shorter sleep duration (per hour less) and greater sleep fragmentation (per 1 percent more) correlated with greater decline in estimated glomerular filtration rate (−1.12 and 0.18 ml/min/1.73 m²/year, respectively) and greater log-urine protein-to-creatinine ratio slope (0.06 and 0.01/year, respectively), in adjusted models. In the fully-adjusted model, self-reported daytime sleepiness correlated with increased risk for all-cause death (hazard ratio, 1.11 per one-point increase in Epworth Sleepiness Scale).

"These findings suggest that short and poor quality sleep are unrecognized risk factors for CKD progression," the authors write.

Abstract
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