Diabetes and Heart Failure Outcomes: What's the Link?

Increased cumulative rates of one-year all-cause death, CVD death, heart failure hospitalization
Increased cumulative rates of one-year all-cause death, CVD death, heart failure hospitalization

HealthDay News — For outpatients with chronic heart failure, diabetes is associated with increased risk of one-year adverse outcomes, according to a study published online March 2 in Diabetes Care.

Marco Dauriz, MD, from the University and Azienda Ospedaliera Universitaria Integrata of Verona in Italy, and colleagues examined whether diabetes status independently affects the one-year risk of all-cause and cardiovascular disease (CVD) mortality and first hospitalization for heart failure in a cohort of 9,428 outpatients with chronic heart failure.

The researchers found that patients with diabetes had higher cumulative rates of one-year all-cause death (9.4 versus 7.2%; adjusted hazard ratio, 1.28; 95% confidence interval, 1.07 to 1.54), CVD death (4.8 versus 3.8%; adjusted hazard ratio, 1.28; 95% confidence interval, 0.99 to 1.66), and heart failure hospitalization (13.8 versus 9.3%; adjusted hazard ratio, 1.37; 95% confidence interval, 1.17 to 1.60), compared with those without diabetes, irrespective of confounding variables. There was a significant and independent association between increasing hemoglobin A1c level with the risk of one-year survival outcomes among the 2,567 patients with hemoglobin A1c measurements available at baseline. 

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"The presence of diabetes markedly increases the risk of one-year adverse clinical outcomes in outpatients with chronic heart failure independent of multiple common risk factors," the authors write. "More effective and personalized treatment for diabetes should be considered in this particularly high-risk patient population."

Several authors disclosed financial ties to the pharmaceutical and medical device industries. Several pharmaceutical companies provided support for the EURObservational Research Program.

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