CDC Warns of Drug-Resistant Gonorrhea
the MPR take:
A recent study by the CDC is warning that while rates of gonorrhea have declined since the 1970s, new drug-resistant strains are becoming more prevalent. In their analysis, rates of gonorrhea from 1991–2006 in 17 cities were evaluated and a strong positive association between resistance to the antibiotic ciprofloxacin and gonorrhea incidence rates was found. Although rates of gonorrhea were higher in cities with lower resistance to drugs, cities with a higher resistance had elevated reports of gonorrhea. The CDC no longer recommends ciprofloxacin or other fluoroquinolones as first-line treatment. Because gonococcal susceptibility to cephalosporins has been decreasing (eliminating cefixime as an option), dual therapy with ceftriaxone and a second antimicrobial drug is the only remaining recommended first-line treatment option for gonorrhea. However, the effectiveness of this regimen may be threatened with the possible emergence and spread of cephalosporin resistance.
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