Cancer Risks in Premenopausal Abnormal Uterine Bleeding Assessed

Low risk of endometrial cancer, atypical hyperplasia in premenopausal women with abnormal bleeding
Low risk of endometrial cancer, atypical hyperplasia in premenopausal women with abnormal bleeding

HealthDay News — Premenopausal women with abnormal uterine bleeding have low risk of endometrial cancer and atypical hyperplasia, according to a review published online October 20 in BJOG: An International Journal of Obstetrics and Gynaecology.

Mary E. Pennant, from Cambridgeshire County Council in the United Kingdom, and colleagues conducted a systematic literature review to examine the risk of endometrial cancer and atypical hyperplasia in premenopausal women with abnormal uterine bleeding. Data were included from 65 articles.

The researchers found that the risk of endometrial cancer was 0.33% (95% confidence interval [CI], 0.23 to 0.48) and risk of endometrial cancer or atypical hyperplasia was 1.31% (95% CI, 0.96 to 1.80). Women with heavy menstrual bleeding had lower risk of endometrial cancer compared to those with inter-menstrual bleeding (0.11 percent [95% CI, 0.04 to 0.32] versus 0.52% [95% CI, 0.23 to 1.16]). No cases of atypical hyperplasia were identified in the five studies reporting the rate among women with heavy menstrual bleeding.

"Premenopausal women with abnormal uterine bleeding should first undergo conventional medical management. Where this fails, the presence of inter-menstrual bleeding and older age may be indicators for further investigation," the authors write. "Further research into the risks associated with age and the cumulative risk of comorbidities is needed."

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