Can Statins Help Treat MS?
the MPR take:
A study published in The Lancet points to a potentially new treatment option for secondary progressive multiple sclerosis (MS). In this phase 2 study, patients received either an 80mg dose of the statin drug simvastatin or placebo. The primary endpoint was annualized rate of whole-brain atrophy. The researchers concluded that compared to placebo, high-dose simvastatin reduced the rate of whole-brain atrophy by 43%. More research will be needed before a recommendation for use in MS patients can be made. In 2011, the FDA recommended limiting the use of simvastatin 80mg because of an increased risk of myopathy. The most serious form of myopathy, rhabdomyolysis, can damage the kidneys and lead to kidney failure, which can be fatal.
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