Asthma May Decrease Clot Retraction Rate

Reduction in CRR, fibrinolysis rate, FEV<sub>1</sub> in asthma versus healthy controls; increase in clot density
Reduction in CRR, fibrinolysis rate, FEV1 in asthma versus healthy controls; increase in clot density

HealthDay News — Clot retraction rate (CRR) and fibrinolysis rate (FR) are reduced in steroid-naive asthma, according to a study published online October 14 in Allergy.

Maria M. Tomasiak-Lozowska, MD, PhD, from the Medical University of Bialystok in Poland, and colleagues assessed CRR, FR, clot density (CD), plasma levels of plasminogen activator inhibitor (PAI-1) and factor XIII (FXIII), nitric oxide (NO) in exhaled breath (FENO), spirometry (forced expiratory volume in one second [FEV1]), and eosinophil count (EOS) in allergic, steroid-naive asthma patients (36 patients) and healthy controls (34 patients). 

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The researchers found that, compared with controls, patients with asthma had significant reductions in CRR, FR, and FEV1, and increases in FENO, EOS, PAI-1, FXIII, and CD (all P<0.001). There was a negative correlation for FR with CD, FXIII, PAI-1, FENO, and EOS, and a positive correlation with FEV1. A positive correlation was seen for FXIII with CD. A negative correlation was seen for CRR with FENO and a positive correlation with FEV1 (all P<0.001).

"These novel findings suggest that asthma itself is associated with decreased CRR and reduced fibrinolytic potential resulting from alterations in clot architecture and elevated levels of plasma FXIII and PAI-1," the authors write.

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