Vitamin D and Reproductive Treatment Outcomes: What's the Link?

Women replete in vitamin D more likely to have live birth, positive pregnancy test, clinical pregnancy
Women replete in vitamin D more likely to have live birth, positive pregnancy test, clinical pregnancy

HealthDay News — For women undergoing assisted reproductive treatment (ART), those who are replete in vitamin D have better outcomes, including live birth, a positive pregnancy test, and clinical pregnancy, according to a review published online November 14 in Human Reproduction.

Justin Chu, MB ChB, from the University of Birmingham in the United Kingdom, and colleagues conducted a systematic review and meta-analysis of 11 published cohort studies that included 2,700 women and examined the correlation between vitamin D and ART outcomes. 

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Based on data from 7 studies that reported live birth (including 2,026 patients), the researchers found that live birth was more likely in women replete with vitamin D versus those with vitamin D deficiency or insufficiency (odds ratio, 1.33). In 5 studies with 1,700 women, the likelihood of achieving a positive pregnancy test was higher for women replete in vitamin D versus those who were deficient or insufficient in vitamin D (odds ratio, 1.34). Based on data from all 11 studies, the likelihood of clinical pregnancy was higher in women replete with vitamin D (odds ratio, 1.46). There was no correlation for miscarriage with vitamin D concentration based on data from six studies that included 1,635 patients.

"The findings of this systematic review show that there is an association between vitamin D status and reproductive treatment outcomes achieved in women undergoing ART," the authors write. "Our results show that vitamin D deficiency and insufficiency could be important conditions to treat in women considering ARTs."

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