Antibiotic Use in Youth May Up Adolescent Prediabetes Risk
Young children who take antibiotics may disrupt their gut microbes and be more likely to develop adolescent prediabetes. Findings from the study were presented at ENDO 2016.
Dr. Stefanaki and colleagues examined the differences in intestinal ecosystem in male and female adolescents aged 12–17 years old to better determine the relationship between the gut microbiome and prediabetes. They analyzed fecal samples of 10 prediabetic adolescents and 14 healthy controls. Study patients with prediabetes reported taking antibiotics >3 times a year by age 3. These patients also had fewer Colony Forming Units (CFUs) of Ruminococcusspecies per gram of stool. Ruminococcus species supports the gut's beneficial bacteria and its depletion can cause negative changes in the gut flora, which may lead to adolescent prediabetes.
In contrast, the healthy controls were 8.5 times less likely to have taken antibiotics by age 3 and 1.75 times less likely to have a positive family history of autoimmune diseases.
Study authors suggest that prebiotics and probiotics may help restore proper balance in the gut bacteria and help prevent prediabetes and ultimately its progression to diabetes.
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