Age and Start of Treatment Are Key to Positive Outcomes in Cystic Fibrosis

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Early treatment of <i>Pseudomonas aeruginosa</i> can eradicate bacteria, delay chronic colonization
Early treatment of Pseudomonas aeruginosa can eradicate bacteria, delay chronic colonization

HealthDay News — For patients with cystic fibrosis (CF), early treatment of Pseudomonas aeruginosa (Pa) may be beneficial, according to a study published online June 16 in the Journal of Clinical Pharmacy and Therapeutics.

Nagehan Emiralioglu, MD, from the Hacettepe University Faculty of Medicine in Ankara, Turkey, and colleagues examined the demographic, clinical, and microbiological data for 146 CF patients with first Pa isolation in sputum culture. The factors that affected the eradication of Pa infection were examined.

The researchers found that patients had a mean age of 71.5 months when Pa was first isolated. The most common treatment choices included 2 weeks of intravenous ceftazidim-amikacin for severe exacerbation or 3 months of inhaled gentamycin plus 3 weeks of oral ciprofloxacin for mild exacerbation. Eradication was observed in 32%, intermittent colonization in 28%, chronic colonization in 40% with these treatment regimens. Patients with chronic colonization had a significant decline in forced expiratory volume in 1 second (P=0.006). There was a negative correlation between being older than 2 years of age or having symptoms at the first Pa isolation and treatment success.

"Early antibiotic treatment for Pa can eradicate the bacteria, prevent or delay the development of chronic colonization, and improve the general health status," the authors write. "The acquisition of Pa at an older age and having symptoms at first isolation negatively affected the success of eradication."

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