Acute bacterial skin and skin structure infections (ABSSSI) caused by the following susceptible Gram (+) organisms
Relapsed or refractory peripheral T-cell lymphoma (PTCL)
Initial monotherapy and adjunct in partial onset or primary generalized tonic-clonic seizures.
To reduce thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD).
Moderately-to-severely active ulcerative colitis.
Emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or CNS depression.
Pulmonary arterial hypertension (PAH) (WHO Group 1) in patients with WHO functional Class II–III symptoms, to improve exercise capacity.
Treatment of patients with anaplastic lymphoma kinase-positive metastatic non-small cell lung cancer who have progressed on or are intolerant to crizotinib.