Long-term maintenance treatment of airflow obstruction in COPD, including chronic bronchitis and/or emphysema.
Routine prophylaxis of bleeding in patients with congenital factor XIII (FXIII) A-subunit deficiency.
Mucopolysaccharidosis type IVA (MPS IVA; Morquio A syndrome).
Management of adults with severe, active rheumatoid arthritis (RA) or children with active polyarticular juvenile idiopathic arthritis (pJIA).
Management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.
Treatment of moderate-to-severe vasomotor symptoms associated with menopause. Prevention of postmenopausal osteoporosis.
Treatment of patients with mantle cell lymphoma (MCL) or chronic lymphocytic leukemia (CLL) who have received at least one prior therapy.
Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.