Neurologic Disorders

Does Adding Evolocumab to Statin Tx Impact Cognitive Function?

August 17, 2017

The researchers found that the mean change from baseline over time in the raw score for the spatial working memory strategy index of executive function was −0.21 ± 2.62 and −0.29 ± 2.81 in the evolocumab and placebo groups, respectively.

Study Reveals Diverse Neurologic Complications with Zika Virus

August 15, 2017

Forty patients were enrolled, including 29 with Guillain-Barré syndrome (GBS), 7 with encephalitis, 3 with transverse myelitis, and 1 with newly diagnosed chronic inflammatory demyelinating polyneuropathy. Diverse Spectrum of Neurologic Syndromes Seen With Zika

Does Antiepileptic Drug Use Contribute to Adverse Pregnancy Outcomes?

By August 14, 2017

Women with epilepsy were at increased risk of adverse pregnancy and delivery outcomes.

How Prevalent Is Epilepsy in the United States?

August 14, 2017

Increases in the number of persons with active epilepsy were indicated based on National Health Interview Survey data from 2010 to 2015, probably due to population growth.

'Groundbreaking' Technology Heals Serious Injuries with a Single Touch

By August 09, 2017

"By using our novel nanochip technology, injured or compromised organs can be replaced. We have shown that skin is a fertile land where we can grow the elements of any organ that is declining," said Dr. Chandan Sen.

Brexanolone Examined in Super-Refractory Status Epilepticus

August 09, 2017

The response end point of weaning successfully off TLAs before tapering brexanolone was met by 17 patients (77%).

Dimethyl Fumarate and Oral Contraceptives: Drug Interactions Explored

By August 08, 2017

Delayed-release DMF exerts anti-inflammatory and neuroprotective properties for the treatment of relapsing multiple sclerosis, a disease that often develops in women between the ages of 20 and 40.

Interactions Identified Between Cannabidiol, Antiepileptic Drugs

August 08, 2017

The researchers observed significant increases in topiramate, rufinamide, and N-desmethylclobazam and a significant decrease in clobazam serum levels with increasing cannabidiol dose.

Radicava Now Available for the Treatment of ALS

By August 08, 2017

Radicava is supplied as a 30mg/100mL solution for intravenous infusion in single-dose polypropylene bags.

Memantine Started Quickly After TBI May Reduce Levels of Brain Damage Biomarker

By August 04, 2017

Before study initiation, NSE levels were similar for both groups. On Day 3 of the study, the NSE levels were 7.95 ± 2.86 ng/mL for the memantine group and 12.33 ± 7.09 ng/mL for the control group (P=0.05).

Antiepileptic Drugs Compared for Partial Onset, Generalized Seizure Types

August 02, 2017

The researchers found that for individuals with partial seizures, levetiracetam performed statistically significantly better than carbamazepine and lamotrigine for time to withdrawal of allocated treatment.

Fluoroquinolones May Up Risk of PTCS, a Rare But Serious Condition

By August 01, 2017

For this study, the researchers examined data from the LifeLink Database for cases with ICD-9-CM code for benign intracranial hypertension (BIH) as well as an MRI or CT scan and a lumbar puncture within 15 or 30 days of the BIH code.

Dementia Risk Up in Older Patients with Hearing Loss

July 31, 2017

The researchers found that in cross-sectional analyses, participants with self-reported or objective moderate and poor hearing were more likely to have a dementia diagnosis than those with normal hearing, after adjustment for potential confounders.

Parkinsonism Treatments

July 28, 2017

Parkinson's drug treatment chart categorized by pharmacological class.

Demystifying Conversion Disorder: A Guide for Primary Care Clinicians

By July 26, 2017

Assessing conversion disorder and distinguishing it from other conditions can be challenging.

CTE Identified in Nearly All Donated Brains from NFL Players

July 26, 2017

Researchers found evidence of the degenerative brain disease in 110 out of 111 deceased NFL players

Angioedema Risk Evaluated for Levetiracetam Versus Phenytoin

By July 25, 2017

"The results suggest that levetiracetam has the same or lower risk for angioedema than phenytoin," wrote the researchers.

ALS-Related Muscle Cramp Drug Gains Fast Track Status

By July 25, 2017

Two Phase 2 trials of FLX-787 titled COMMAND and COMMIT are expected to start in the U.S. this quarter in ALS and Charcot-Marie-Tooth (CMT) patient populations, respectively.

Is Fasting Plasma Glucose a Predictor of Alzheimer's in T2D?

July 25, 2017

Both FPG CV and HbA1c CV were significant predictors of AD after adjustment for sociodemographic factors, lifestyle behaviors, diabetes-related variables, FPG and HbA1c, drug-related variables, and comorbidities.

Multiple Sclerosis Treatments

July 25, 2017

Inclusive list of disease modifying medications FDA approved for multiple sclerosis.

fMRI, EEG May Benefit Traumatic Brain Injury Patients in the ICU

July 24, 2017

Bedside exams often miss subtle signs Early detection of consciousness and brain function in the intensive care unit could allow families to make more informed decisions about the care of loved ones," co-lead author Brian Edlow.

Study Aims to "Set the Record Straight" on PPIs and Dementia

By July 20, 2017

After multivariable adjustment - which included duration of chronic medical conditions - a modest statistically significant association was only seen for psychomotor speed and attention.

PANS/PANDAS Treatment Guidelines Released

By July 20, 2017

"Immunomodulatory therapy should be considered early, because NSAIDs or a short course of oral corticosteroids may be sufficient for symptom remission in recent-onset cases, whereas those with long-standing symptoms often require more intensive and prolonged immunotherapeutic interventions," the authors write.

The Puzzles That May Improve Brain Performance

July 18, 2017

"We found direct relationships between the frequency of word puzzle use and the speed and accuracy of performance on nine cognitive tasks assessing a range of aspects of function including attention, reasoning, and memory," researcher Keith Wesnes, PhD.

ALS, Parkinson's Mortality Tied to Certain Occupations

July 14, 2017

Occupations associated with higher education and income show increased mortality risk

Maternal Antidepressant Use and Offspring Disability: What's the Link?

July 13, 2017

No significant association for use of antidepressant in pregnancy, child's intellectual disability

MS Risk May Be Lower for Mothers Who Breastfeed

July 13, 2017

Benefits reported for women who nursed 15 months or more

Early Biomarker May Help Differentiate Parkinsonism Disorders

July 12, 2017

Magnetic resonance imaging (T1-weighted and diffusion-weighted imaging) with a 3-T magnetic resonance imager revealed that the Parkinson's patients had significant alterations in optic radiation connectivity distribution.

Switching from Tetrabenazine to Deutetrabenazine Evaluated in Huntington's Disease

By July 11, 2017

Study authors concluded that patients taking tetrabenazine three times daily can safely be converted to deutetrabenazine twice daily, while maintaining chorea control.

Xadago Available as Adjunct Therapy for Parkinson's Disease

By July 11, 2017

Patients taking Xadago also experienced less "off" time and better scores on a measure of motor function performed during "on" time vs. prior to treatment.